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22Na and36Cl fluxes in isolated human cornea preparations were measured under short-circuited conditions. At pH 7.3–pH 7.6 sodium net flux was directed from aqueous humour to tear side, chloride net flux was statistically not different from zero. Alkalinization of the bathing solution to pH 8.6 stimulated unidirectional sodium and chloride fluxes from(More)
Several efficient transitive closure algorithms operate on the strongly connected components of a digraph, some of them using Tarjan's algorithm [17]. Exploiting facts from graph theory and the special properties of Tarjan's algorithm we develop a new, improved algorithm. The transitive reduction of a digraph defined in [1] may be obtained as a byproduct.(More)
OBJECTIVES The aim of this study was to set up reference values for Doppler flow-derived left ventricular filling parameters and to evaluate physiologic determinants of changes in signal expression related to maturation. BACKGROUND In left ventricular diastolic function studies, age-related modulations in signal expression are observed. Assuming(More)
Transmitral flow parameters in preterm and term infants were compared in order to study differences in signal expression and temporal dynamics of left ventricular diastolic function. In 63 preterm infants between 26 and 33 weeks of gestation and 102 term infants, a Doppler survey was performed during 6 months after birth. Early and atrial filling-time(More)
In very low birth weight neonates, a left-to-right shunt via persistent ductus arteriosus (PDA) may interact with diastolic left ventricular function, but specific changes of Doppler parameters have yet to be reported. In a serial transmitral Doppler study, we investigated the impact of a PDA on diastolic function parameters. Twenty-two patients with and(More)
Signals from 37 magnetocardiographic sensors and simultaneously recorded 32 ECG leads were obtained in three healthy male subjects (including two reinvestigations). After recordings at rest, the heart rate was increased by pharmacologic stress (117 to 142 beats/min). Comparison of the repolarization of rest and stress showed substantial changes in the(More)
OBJECTIVE To assess the prevalence and detection rate of major anomalies (MAs) by applying first trimester anomaly scan (FTAS) including first trimester fetal echocardiography (FTFE) to all fetuses and discuss ethical implications. METHODS The study group included 6879 consecutive fetuses with known outcome of pregnancy (follow-up: 98%), 6565 with(More)
BACKGROUND Preterm infants may have cardiac stress related to patent ductus arteriosus (PDA) or bronchopulmonary dysplasia (BPD). In this study, we examined the development of cardiac function in preterm infants by measuring tissue Doppler-derived peak systolic strain (PSS) and strain rate (PSSR) in the first 28 days of life. METHODS Peak systolic strain(More)
OBJECTIVES In preterm infants, postnatal myocardial adaptation may be complicated by bronchopulmonary dysplasia (BPD). We aimed to describe the development of left ventricular function by serial 2D, Doppler, and speckle tracking echocardiography (2D-STE) in infants with and without BPD during the neonatal period and compare these to anthropometric and(More)