Lothar A. Schwarte

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Conventional cardiovascular monitoring may not detect tissue hypoxia, and conventional cardiovascular support aiming at global hemodynamics may not restore tissue oxygenation. NIRS offers non-invasive online monitoring of tissue oxygenation in a wide range of clinical scenarios. NIRS monitoring is commonly used to measure cerebral oxygenation (rSO(2)), e.g.(More)
Maintenance or restoration of adequate tissue oxygenation is a main goal of anesthesiologic and intensive care patient management. Pathophysiological disturbances which interfere with aerobic metabolism may occur at any stage in the oxygen cascade from atmospheric gas to the mitochondria, and there is no single monitoring modality that allows comprehensive(More)
BACKGROUND Perioperative disturbances of microvascular blood flow and oxygenation in the intestinal tract have been hypothesized to play an important role in development of the multiple organ dysfunction syndrome. Herein, increased intra-abdominal pressure (IAP) has been identified as a key factor in the initiation of the pathophysiologic cascade. The(More)
PURPOSE To study the effects of pretreatment with levosimendan (LEVO, a Ca²(+)-sensitizer and K (ATP) (+) channel opener) and/or the K (ATP) (+) channel antagonist glibenclamide (GLIB) on systemic hemodynamics, metabolism, and regional gastromucosal oxygenation during hypoxic hypoxemia. METHODS Chronically instrumented, healthy dogs (24-32 kg, n = 6 per(More)
STUDY OBJECTIVE Public accessible automated external defibrillators (AEDs) are increasingly made available in highly frequented places, allowing coincidental bystanders to defibrillate with minimal delay if necessary. Although the public, as the largest and most readily available group of potential rescuers, is assigned a key role in this concept of(More)
BACKGROUND Adequate gastrointestinal mucosal oxygenation is regarded to be crucial in the prevention and therapy of critical illness. Epinephrine and norepinephrine are used for perioperative haemodynamic support. However, their per se effects on gastromucosal haemoglobin oxygenation (μHbO(2)) remain unclear. Moreover, respective effects of epinephrine and(More)
Monitoring of aortic blood flow, conducting large portions of the cardiac output (CO), allows conclusions on the global hemodynamic status of patients. For this purpose, transesophageal Doppler (TED) devices have been developed, which interrogate the descending aorta and calculate aortic blood flow velocity using the Doppler principle. The recorded(More)
BACKGROUND In this study we aimed to clarify the role of endothelin in arterial pressure regulation during anaesthesia with increasing concentrations of sevoflurane (1-3 MAC) and compare it with those of vasopressin and angiotensin. METHODS After an awake control period, on different days, six dogs underwent each of the following four interventions:(More)
BACKGROUND This study was designed to examine whether the coupling between oxygen consumption (VO2) and cardiac output (CO) is maintained during xenon anaesthesia. METHODS We studied the relationship between VO2 (indirect calorimetry) and CO (ultrasound flowmetry) by adding xenon to isoflurane anaesthesia in five chronically instrumented dogs. Different(More)
[ 11 C]phenytoin quantification using parametric methods Abstract Purpose: In this study the performance of various methods for generating quantitative para-metric images of dynamic [ 11 C]phenytoin PET studies will be evaluated. Procedures: Double baseline 60 min dynamic [ 11 C]phenytoin PET studies, including online arterial sampling, were acquired for 6(More)