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Mu-opioid analgesics are a mainstay in the treatment of acute and chronic pain of multiple origins, but their side effects, such as constipation, respiratory depression, and abuse liability, adversely affect patients. The recent demonstration of the up-regulation and membrane targeting of the delta-opioid receptor (DOR) following inflammation and the(More)
Neuropathic pain results from injury or dysfunction of the central or peripheral nervous system. The treatment of neuropathic pain is challenging, in part because of its multiple etiologies. The present study explores combinations of the analgesic tramadol and each of four anticonvulsants in the treatment of surgically induced (ligation of the L5 spinal(More)
A number of studies in the past have indicated that certain types of dopamine receptor-mediated behaviours can be reversed by serotonin agonists. We have recently described a behavior in neonatal rats induced by the selective D1 receptor agonist SKF 38393, which we termed vacillatory behavior. The current study was aimed at determining the effectiveness of(More)
SKF 38393 was administered to postnatal rat pups on day 15 and day 30. Behaviors measured on day 15 revealed that SKF 38393-treated groups displayed significant deficits, in comparison to controls, in spontaneous alternation and decision-making: less alternation and more vacillatory behavior at every dosage tested. On day 30, all SKF 38393-related behaviors(More)
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