Lorraine Pawson

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Pacinian corpuscles (PCs) are tactile receptors composed of a nerve ending (neurite) that is encapsulated by layers of lamellar cells. PCs are classified as primary mechanoreceptors because there is no synapse between the transductive membrane and the site of action-potential generation. These touch receptors respond in a rapidly adapting manner to(More)
It has long been accepted that action potentials arising from Pacinian corpuscles (PCs) originate at the first node of Ranvier located within the PC and that the mechanotransduction events (receptor potentials) are formed by stretch-activated channels selectively sensitive predominantly to Na+. Also, it has been shown previously that tetrodotoxin (TTX)(More)
Light- and electron-microscopic immunocytochemistry (ICC) was performed on Pacinian corpuscles (PCs) obtained from cat mesentery to determine the presence and location of various proteins within the accessory capsule and the neurite. Antibodies to tubulin, neurofilament 200, actin, collagen II and V, glial fibrillary acidic protein (GFAP) and S-100 were(More)
The role of the capsule encasing the Pacinian corpuscle's (PC's) neurite, where mechanotransduction occurs, may be more than mechanical. The inner core of the PC's capsule consists of lamellar cells that are of Schwann-cell origin. Previously, we found both voltage-gated Na+ and K+ channels in these inner-core lamellae. Research on astrocytes and Schwann(More)
Heart rates of healthy cows and cows suspected of having bovine spongiform encephalopathy were measured by auscultation and by a portable cardiac monitor. Bradycardia was demonstrated in suspect cases which were confirmed histopathologically. Disturbances in cardiac rhythm were also evident in some cases. Healthy cows deprived of food exhibited bradycardia.(More)
Extracellular recording from single auditory nerve fibres in the lizard,Gekko gecko, revealed interesting patterns of evoked and spontaneous activity. The fibres are sensitive and sharply tuned (Figs. 1 and 3) and have characteristic frequencies (CFs) from 0.15 to 5 kHz (Fig. 2). Responses to pure tone bursts fall into three main categories with different(More)
A novel hierarchical clustering algorithm was applied to the distribution of Meissner corpuscles in the skin of mammals. This method, called end-to-end linkage (EEL), is useful for grouping data that consists of chain-like contingencies in the multivariable space. Unlike the traditional techniques which uncover hyperspherical clusters (e.g. single linkage),(More)
Glia are increasingly appreciated as active participants in central neural processing via calcium waves, electrical coupling, and even synaptic-like release of "neuro"-transmitters. In some sensory organs (e.g., retina, olfactory bulb), glia have been shown to interact with neurons in the same manner, although their role in perception has yet to be(More)
Reconstructing neural-population responses in the form of spatial event plots assumes that the receptors are organized in a dense linear array. We have found that this assumption is not valid by determining the spatial organization of Meissner corpuscles (MCs) in the glabrous skin of both cat and monkey. The tissue was excised from animals that had been(More)
The Merkel cell-neurite complex is considered to be one class of mechanoreceptors in the skin. Merkel cells are innervated by slowly adapting type I (SAI) tactile nerve fibers. In this paper, the detailed distribution of Merkel cells is studied by immunohistochemical labeling of the monkey (Macaca fascicularis) digital glabrous skin. Specific morphometric(More)