Lorianne Masuoka

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Recent advances in clinical neurophysiology of epilepsy have enhanced our ability to study the epileptogenic region and have improved the localization of seizures in patients with intractable epilepsy. Computed spike analyses using electroencephalogram or magnetoencephalography superimposed on magnetic resonance images define precise relationships between(More)
Naloxegol (previously known as NKTR-118) is a peripherally acting μ-opioid receptor antagonist engineered using polymer conjugate technology in development as an oral, once-daily agent for the treatment of opioid-induced constipation (OIC). Eligible patients with OIC (n=207), defined as <3 spontaneous bowel movements (SBMs) per week with accompanying(More)
The pathophysiological sequelae of the primary spinal cord injury (SCI) include edema, spinal cord swelling, reduced blood flow, and local tissue ischemia resulting in further cellular necrosis culminating in the appearance of a tissue void (cavity). Biodegradable scaffolds can be implanted within the necrotic lesion to fill this void and provide structural(More)
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