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A protein interaction network of the malaria parasite Plasmodium falciparum.

• Douglas J Lacount, Marissa Vignali, +9 authors Robert E. Hughes
• Nature
• 2005

Plasmodium falciparum causes the most severe form of malaria and kills up to 2.7 million people annually. Despite the global importance of P. falciparum, the vast majority of its proteins have not… (More)

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes.

• Hsien-hsien Chiang, Lori Schoenfeld, +11 authors David P. Bartel
• Genes & development
• 2010

MicroRNAs (miRNAs) are small regulatory RNAs that derive from distinctive hairpin transcripts. To learn more about the miRNAs of mammals, we sequenced 60 million small RNAs from mouse brain, ovary,… (More)

A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met.

• Ly Phan, Lori Schoenfeld, Leoš Shivaya Valášek, Klaus Nielsen, Alan G Hinnebusch
• The EMBO journal
• 2001

Yeast translation initiation factor 3 contains five core subunits (known as TIF32, PRT1, NIP1, TIF34 and TIF35) and a less tightly associated component known as HCR1. We found that a stable… (More)

A facile method for high-throughput co-expression of protein pairs.

• Andrei V. Alexandrov, Marissa Vignali, +11 authors Elizabeth J. Grayhack
• Molecular & cellular proteomics : MCP
• 2004

We developed a method to co-express protein pairs from collections of otherwise identical Escherichia coli plasmids expressing different ORFs by incorporating a 61-nucleotide sequence (LINK) into the… (More)

Discovery of an Unconventional Centromere in Budding Yeast Redefines Evolution of Point Centromeres

• Norihiko Kobayashi, Yutaka Suzuki, +4 authors Tomoyuki U Tanaka
• Current Biology
• 2015

Centromeres are the chromosomal regions promoting kinetochore assembly for chromosome segregation. In many eukaryotes, the centromere consists of up to mega base pairs of DNA. On such "regional… (More)

Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding.

• Leoš Shivaya Valášek, Ly Phan, Lori Schoenfeld, Vendula Valášková, Alan G Hinnebusch
• The EMBO journal
• 2001

eIF3 binds to 40S ribosomal subunits and stimulates recruitment of Met-tRNAiMet and mRNA to the pre-initiation complex. Saccharomyces cerevisiae contains an ortholog of human eIF3 subunit p35, HCR1,… (More)

A multifactor complex of eIF1, eIF2, eIF3, eIF5, and tRNA(i)Met promotes initiation complex assembly and couples GTP hydrolysis to AUG recognition.

• Kazuhito Asano, Ly Phan, +6 authors Alan G Hinnebusch
• Cold Spring Harbor symposia on quantitative…
• 2001

Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.

• Jürgen Bosch, Mark A. Robien, +22 authors Wim G. J. Hol
• Journal of medicinal chemistry
• 2006

The 1.8 A resolution de novo structure of nucleoside 2-deoxyribosyltransferase (EC 2.4.2.6) from Trypanosoma brucei (TbNDRT) has been determined by SADa phasing in an unliganded state and several… (More)

Structural genomics of pathogenic protozoa: an overview.

• Erkang Fan, David Baker, +36 authors Wim G. J. Hol
• Methods in molecular biology
• 2008

The Structural Genomics of Pathogenic Protozoa (SGPP) Consortium aimed to determine crystal structures of proteins from trypanosomatid and malaria parasites in a high throughput manner. The pipeline… (More)

Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site.

• Mark A. Robien, Jürgen Bosch, +19 authors Wim G. J. Hol
• Proteins
• 2006

The crystal structure of D-glyceraldehyde-3-phosphate dehydrogenase (PfGAPDH) from the major malaria parasite Plasmodium falciparum is solved at 2.25 A resolution. The structure of PfGAPDH is of… (More)

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