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Cancer cachexia is regulated by selective targeting of skeletal muscle gene products.

• Swarnali Acharyya, Katherine J. Ladner, +4 authors Denis C. Guttridge
• The Journal of clinical investigation
• 2004

Cachexia is a syndrome characterized by wasting of skeletal muscle and contributes to nearly one-third of all cancer deaths. Cytokines and tumor factors mediate wasting by suppressing muscle gene… (More)

Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer.

• Rachel Pearlman, Wendy L. Frankel, +42 authors Heather Hampel
• JAMA oncology
• 2017

Importance Hereditary cancer syndromes infer high cancer risks and require intensive cancer surveillance, yet the prevalence and spectrum of these conditions among unselected patients with… (More)

The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.

• Kim C Mansky, Sabine Sulzbacher, +4 authors Michael C. Ostrowski
• Journal of leukocyte biology
• 2002

The microphthalmia transcription factor (MITF) regulates different target genes in several distinct cell types, including osteoclasts. The role of the closely related factors TFE3 and TFEC in MITF… (More)

Activation of the ras-Mitogen-activated Protein Kinase Pathway and Phosphorylation of ets-2 at Position Threonine 72 in Human Ovarian Cancer Cell Lines1

• Suzanne E. Patton, Michele L. Martin, +4 authors Michael C. Ostrowski
• 2006

The activation status of the ms pathway was studied in eight ovarian tumor cell lines. Three biochemical parameters indicative otras activation were tested: (a) the ratio of the ras-GTP:ras-GDP… (More)

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