Learn More
The purpose of this study was to explore the functional role of the cytoplasmic domain of the ct subunit of the o~5//31 integrin, a fibronectin receptor. Mutant CHO cells that express very low levels of en-dogenous hamster a5 subunit (CHO clone B2) were transfected with an expression vector containing full-length or truncated human a5 cDNAs to form(More)
PURPOSE Given distinct mechanism of actions of enzastaurin and bevacizumab, preclinical studies suggest enhanced antitumor activity in combination. This phase I study assessed the combination's safety and efficacy. PATIENTS AND METHODS Six advanced cancer patients could be enrolled in each of 11 cohorts. Patients received an enzastaurin loading dose. Oral(More)
  • 1