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Otoacoustic emissions were measured in 42 normal hearing subjects ranging from 20 to 80 years old. For each subject spontaneous, click-evoked, tone-burst-evoked, stimulus frequency and distortion product emissions were measured across a wide intensity range for frequencies between 1 and 3 kHz. Although there are significant differences between age groups,(More)
A novel analysis approach has been developed to examine the latency of distortion product otoacoustic emissions (DPOAEs). DPOAEs were measured in ten normal-hearing adults in a paradigm in which f2 was held constant and f1 was varied. This paradigm was used with a wide range of primary levels. Latency was estimated in two ways. In the first, a phase-slope(More)
Detailed modeling and simulation of biochemical systems is complicated by the problem of combinatorial complexity, an explosion in the number of species and reactions due to myriad protein-protein interactions and post-translational modifications. Rule-based modeling overcomes this problem by representing molecules as structured objects and encoding their(More)
This study examined the effect of primary stimulus level on the ability of distortion product otoacoustic emission (DPOAE) measurements to separate normal-hearing from hearing-impaired ears. Complete I/O functions were obtained for nine f2 frequencies on 210 people approximately evenly divided between normal hearing and hearing impaired. Clinical decision(More)
Distortion product otoacoustic emission (DPOAE) input/output functions were measured at nine f2 frequencies ranging from 500 to 8000 Hz in 210 normal-hearing and hearing-impaired subjects. In a companion paper [Stover et al., J. Acoust. Soc. Am. 100, 956-967 (1996)], L1-L2 was held constant at 10 dB, and L2 was varied from 65 to 10 dB SPL in 5-dB steps.(More)
Attempts to identify the mechanisms underlying tinnitus and to develop effective treatments have been frustrating, in part because there are no objective measures of tinnitus. Following Kemp's initial reports of evoked and spontaneous otoacoustic emissions (OAEs), many people hoped that OAEs were an objective correlate of tinnitus. The results of several(More)
Distortion product otoacoustic emission (DPOAE) frequency functions were measured in normal-hearing and hearing-impaired ears. A fixed-f2/swept-f1 paradigm was used with f2 fixed at half-octave intervals from 1 to 8 kHz. L1 was always 10 dB greater than L2, and L2 was varied from 65 to 10 dB SPL in 5-dB steps. The responses were quantified by the frequency(More)
This study investigated the pitch elicited by complex narrow bandwidth signals. These signals ranged from two-component tones to multiple-component approximations of narrow-band noise. All were contained within 10-, 20-, or 50-Hz bandwidths. Listeners were asked to adjust the frequency of a pure tone to match the pitch they heard in a given complex signal.(More)
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