Lori Daneker

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BACKGROUND Glycine transporter 1 (GlyT1) inhibitors have emerged as potential treatments for schizophrenia due to their potentiation of NMDA receptor activity by modulating the local concentrations of the NMDA co-agonist glycine. [18F]MK-6577 is a potent and selective GlyT1 inhibitor PET tracer. Although differences in ligand kinetics can be expected(More)
Introduction: Amyloid plaque is the hallmark pathology of Alzheimer's Disease (AD). Although it is not conclusive whether amyloid plaque is a cause or a result of AD, anti-amyloid therapeutics which can remove amyloid plaque or inhibit its formation is of great interest. A PET tracer for amyloid plaque may be a useful tool to aid in early diagnosis of AD,(More)
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