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Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted… (More)
Milk Fat Globule--EGF--factor VIII (MFGE8), also called lactadherin, is a secreted protein, which binds extracellularly to phosphatidylserine and to αvβ3 and αvβ5 integrins. On human and mouse cells… (More)
BackgroundUnderstanding and manipulating gene function in physiological conditions is a major objective for both fundamental and applied research. In contrast to other experimental settings, which… (More)
Muscle-invasive forms of urothelial carcinomas are responsible for most mortality in bladder cancer. Finding new treatments for invasive bladder tumours requires adequate animal models to decipher… (More)
La presente invention concerne des anticorps anti-lactadherine et leur utilisation medicale.
La therapie genique et la vectorisation proteique sont deux strategies prometteuses pour le developpement de technologies pharmaceutiques innovantes. Mon travail de these a consiste a utiliser des… (More)