Lorenzo Piola

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This paper reports the synthesis and characterization of trans-cinnamaldehyde thiosemicarbazone (Htcin), cuminaldehyde thiosemicarbazone (Htcum) and their copper and nickel complexes. All the compounds, which on healthy cells (human fibroblasts) show a neglectable cytotoxicity, were screened in vitro in cell line U937 for their antileukemic activity. These(More)
An easily prepared series of phenylindenyldihydridosilyl ruthenium complexes () was obtained by reaction of tertiary silanes with the commercially-available [RuCl(3-phenylindenyl)(PPh3)2] (). The [RuH2(3-phenylindenyl)(SiEt3)] () complex was shown to be highly efficient (1.5 mol%) in the ortho-selective borylation of pyridyl substrates, with yields of up to(More)
An efficient and convenient ruthenium catalysed method for a regiospecific H/D exchange using D2O is described. Organic moieties such as pyridine, oxazole, imidazole, pyrazole, ester, ketone and carboxylic acid have been found effective directing groups in this transformation. In addition, the deuteration of the enantiopure (S)-Ketoprofen leads to the(More)
Since the discovery and now widespread use of olefin metathesis, the evolution of metathesis catalysts towards air stability has become an area of significant interest. In this fascinating area of study, beginning with early systems making use of high oxidation state early transition metal centers that required strict exclusion of water and air, advances(More)
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