Lorenzo Fantini

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In patients with Parkinson's disease who had never previously been treated with any antiparkinsonism drug, we studied the effects of L-dopa on ballistic arm abduction movement in a step-tracking task. L-Dopa treatment increased the mean velocity of the initial movement towards the target without loss of accuracy and with improved motor performance under(More)
OBJECTIVE Periodic leg movements during sleep (PLMS) are often associated with electroencephalographic (EEG) changes, such as microarousals (MA), and with heart rate (HR) variations. The aim of the present study was to evaluate the effects of age and gender on HR changes associated with PLMS in restless legs syndrome (RLS) patients. METHODS Forty-two RLS(More)
In recent years, a number of articles have been published on the treatment of acute pancreatitis in experimental models and most of them concerned animals with mild disease. However, it is difficult to translate these results into clinical practice. For example, infliximab, a monoclonal TNF antibody, was experimentally tested in rats and it was found to(More)
Evidence supporting rechallenge in patients responding to first exposure to trabectedin is limited. We report on a 39-year-old woman with advanced high-grade undifferentiated sarcoma (US) retreated twice with trabectedin after first response. The patient presented in June 2006 with an abdominal mass originating from the rear fascia of the rectus abdominis.(More)
Spatio-temporal parameters of ballistic arm abduction movements were studied in healthy control subjects and in patients with Parkinson's disease. Arm abduction was performed during a step-tracking task. Patients showed longer reaction times, slower mean velocities and lesser accuracy, with a marked tendency to undershooting. In patients, "ballistic"(More)
Age-related changes in spatio-temporal parameters of ballistic arm abduction movements were investigated in two groups of healthy volunteers: a group of younger subjects (aged 20-45 years) and a group of older subjects (aged 60-82 years). Arm abduction was performed in a step-tracking task. Older subjects exhibited longer reaction times, greater durations(More)
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