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BACKGROUND We tested the hypothesis that prophylactic cardiac-resynchronization therapy in the form of biventricular stimulation with a pacemaker with or without a defibrillator would reduce the risk of death and hospitalization among patients with advanced chronic heart failure and intraventricular conduction delays. METHODS A total of 1520 patients who(More)
OBJECTIVE To characterize the feasibility and safety of a wireless networked system incorporating physiologic assessments and direct confirmation of digital tablet ingestions in ambulatory patients with schizophrenia or bipolar disorder. METHOD In this 4-week observational study conducted between May 2010 and May 2011 at 2 US academic clinical study(More)
Poor adherence to tuberculosis (TB) treatment hinders the individual's recovery and threatens public health. Currently, directly observed therapy (DOT) is the standard of care; however, high sustaining costs limit its availability, creating a need for more practical adherence confirmation methods. Techniques such as video monitoring and devices to(More)
The adoption of digital signal processing (DSP) microchips for detection and analysis of electrocardiographic signals offers a means for increased computational speed and the opportunity for design of customized architecture to address real-time requirements. A system using the Motorola 56001 DSP chip has been designed to realize cycle-by-cycle detection(More)
Recent studies have reported a significant false positive rate in delivery of therapy by implantable antitachycardia devices utilizing detection algorithms based on sustained high rate. More selective decision schemes for the recognition of life-threatening arrhythmias have been recently proposed that use analysis of the intrinsic electrogram rather than(More)
<i>Background:</i> A networked wellness system is under development to document actual ingestions of oral medications, to differentiate types/doses of drugs taken simultaneously, and to provide these data along with other metrics to patients and providers for individually tailored care. <i>Methods:</i> After ingestion, an edible sensor (embedded in drug) is(More)
BACKGROUND This open-label single-arm exploratory study evaluated the accuracy of the Ingestible Sensor System (ISS), a novel technology for directly assessing the ingestion of oral medications and treatment adherence. METHODS ISS consists of an ingestible event marker (IEM), a microsensor that becomes activated in gastric fluid, and an adhesive personal(More)
Objective information that can be passively obtained in an ambulatory setting could be potentially useful for determining appropriate care in blood pressure (BP) management. This study utilized digital medicine (DM) prototypes and telemetric data acquisition to directly confirm medication use and to assess habits of daily living in a hypertensive(More)
Over 75,000 antitachycardia devices (ATDs) have been implanted since initial Food and Drug Adrninistra-tion approval in 1985 and have yielded dramatic survival rates. These devices, although life-saving, rely principally on simple measures of the heart rate for arrhythmia detection. The ATDs are highly sensitive, but their low specificity of diagnosis(More)
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