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PURPOSE The multikinase inhibitor sorafenib displays antitumor activity in preclinical models of osteosarcoma. However, in sorafenib-treated patients with metastatic-relapsed osteosarcoma, disease stabilization and tumor shrinkage were short-lived and drug resistance occurred. We explored the sorafenib treatment escape mechanisms to overcome their(More)
Unresectable metastatic bone sarcoma and soft-tissue sarcomas (STS) are incurable due to the inability to eradicate chemoresistant cancer stem-like cells (sCSC) that are likely responsible for relapses and drug resistance. In this study, we investigated the preclinical activity of patient-derived cytokine-induced killer (CIK) cells against autologous bone(More)
PURPOSE After standard multimodal therapy, the prognosis of relapsed and unresectable high-grade osteosarcoma is dismal and unchanged over the last decades. Recently, mitogen-activated protein kinases were shown to be activated in osteosarcoma specimens, suggesting, therefore, they are suitable targets for the multikinase inhibitor sorafenib. Thus, we(More)
BACKGROUND Results of previous study showed promising but short-lived activity of sorafenib in the treatment of patients with unresectable advanced and metastatic osteosarcoma. This treatment failure has been attributed to the mTOR pathway and might therefore be overcome with the addition of mTOR inhibitors. We aimed to investigate the activity of sorafenib(More)
10061 Background: Cardiovascular events (CVE), i.e. CHF and coronary artery disease (CAD), may occur in up to 10% of patients (pts) affected by GIST and RCC treated with SU. CVE recognition, SU interruption and appropriate therapy based on ACE inhibitors and/or β blockers, are the only effective treatment for this severe complication. As of today, CVE known(More)
The purpose of this paper is to study the approximation of vector valued mappings defined on a subset of a normed space. We investigate Korovkin-type conditions under which a given sequence of linear operators becomes a so-called approximation process. First, we give a sufficient condition for this sequence to approximate the class of bounded, uniformly(More)