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OBJECTIVES To review the evidence from controlled clinical trials of neonates given equal daily aminoglycoside doses as extended interval dosing (dosage interval typically 24 hours in term and 36-48 hours in immature neonates) compared with traditional dosing (dosage interval typically 8-12 hours in term and 12-24 hours in immature neonates). DESIGN(More)
BACKGROUND Epidemiological studies have shown an association between gastro-oesophageal reflux disease (GORD) and asthma, and oesophageal acid perfusion may cause bronchial constriction. However, no causative relation has been proven. AIM To assess whether acid suppression would lead to reduced asthma symptoms in children with concomitant asthma and GORD.(More)
Highly active antiretroviral therapy (HAART) may induce dyslipidemia and thus increase the risk of future cardiovascular heart disease (CHD). In this cross-sectional study performed in 2000–2001, the prevalence of a Framingham CHD risk score of >20% in HIV-positive individuals treated or not treated with HAART was compared with that in age- and(More)
Highly active antiretroviral therapy (HAART) may induce dyslipidemia, insulin resistance and body fat distribution similar to that seen in the metabolic syndrome. Hypertension is often a part of the classic metabolic syndrome, but few studies are published about hypertension in HIV-positive patients on HAART. The aim of this study was to compare the(More)
OBJECTIVES The aim of this study was to evaluate the association between genotypic drug resistance and the occurrence of HIV-related diseases and death in HIV-1-infected adults on antiretroviral therapy. METHODS We performed an observational study on patients from an out-patient clinic in a university hospital. Genotypic drug resistance analysis after(More)
Delayed neurotoxicity in hens was reported after the administration of several chlorinated alkyl phosphates. Neurotoxicity increased in a homologous series with the size and/or hydrophobic nature of substituents. In the present study the neurotoxicities of two commercial flame retardants, Fyrol PCF [tri(2-chloropropyl) phosphate] and Fyrol CEF(More)
The rate of bone loss before and after the menopause were studied prospectively in 73 healthy women, who were all aged 47 and premenopausal at the start of the study. Bone mass was measured annually by radiogrammetry of 6 metacarpals and by dual photon absorptiometry of the distal and proximal forearm. The rate of bone loss was nearly linear the first 6(More)
The effect of oral anticholinergic drugs has been limited in the treatment of drooling. Transdermal scopolamine (1.5 mg/2.5 cm2) offers advantages. One single application is considered to render a stable serum concentration for 3 days. A distinct reduction of basal salivation was demonstrated in an open trial of six healthy volunteers. Eighteen mentally(More)
To assess the degree of familial clustering and the mode of inheritance of the polycystic ovarian syndrome (PCO), the prevalence of PCO-related symptoms among first- and second-degree relatives of 132 PCO patients and 71 controls was studied using questionnaire data. 19.7% of male first-degree relatives of PCO patients were reported to have early baldness(More)
OBJECTIVE To evaluate survival and prognostic factors in a consecutive series of colon cancer patients from a defined city population in Norway. METHOD All patients with adenocarcinoma of the colon diagnosed between 1993 and 2000 were registered prospectively. Five-year actuarial survival and 5-year relative survival rates were calculated. Cox regression(More)