Lorena Jung

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The effects of several doses of apomorphine (AP: 0.062-8 mg/kg) on novelty preference (NP) in male Swiss mice were studied. AP induced a dose-dependent reduction of NP as well as of locomotor activity. The decrease in NP appeared to be related to the effect of the drug in reducing locomotion, and may be explained by a drug-induced increase in perseverance(More)
Sleep and circadian disturbances are common among patients with dementia. Symptomatic manifestations vary according to dementia subtype, with one commonly shared pattern--the irregular sleep-wake rhythm (ISWR), a circadian disorder characterized by an absence of the sleepwake cycle’s circadian synchronization. Hypothesized mechanisms of circadian rhythm(More)
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