Lorena Honović

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Increased serum bilirubin levels in patients with Gilbert syndrome (GS) are caused by reduction of hepatic activity of bilirubin glucuronosyltranferase to about 30% of normal. UGT1A1 genetic polymorphism with absent or very low bilirubin UDP-glucuronosyltransferase (B-UGT) activity is associated with Gilbert's syndrome (GS) and other hyperbilirubinemias.(More)
BACKGROUND This cross-sectional multicentric survey study aimed to assess the quality of the extra-analytical phase of laboratory activities in some developing European countries and Mexico. We assessed the quality of the extra-analytical practices in participating laboratories regarding the: a) sample acceptance criteria; b) phlebotomy procedures; c) test(More)
AIM To determine the prevalences of factor V Leiden and the G20210A mutation in the prothrombin gene (PT20210A) and the frequency of their association in healthy subjects and in patients with venous thromboembolism (VTE). METHOD We studied 160 Croatian patients with at least one episode of VTE and 155 healthy subjects as a control group. Genomic DNA was(More)
  • 2014
Quality and safety of laboratory diagnostics are very important and significant affect on the promotion of overall health care. Classification of laboratory diagnostics to preanalytical, analytical and post-analytical phase facilitate the monitoring of the entire laboratory process and the emergence of possible errors. A lot of evidence suggesting that the(More)
Chronic kidney disease (CKD) is a common clinical condition with significant adverse consequences for the patient and it is recognized as a significant public health problem. The role of laboratory medicine in diagnosis and management of CKD is of great importance: the diagnosis and staging are based on estimation of glomerular filtration rate (eGFR) and(More)
Stručni rad Professional paper Summary: Tumor markers are substances, usually proteins that are produced by the body in response to cancer growth or by the cancer tissue itself and they may be detected in blood, urine, or tissue samples. Some tumor markers are specific for a particular type of cancer, while others are seen in several cancer types. Most of(More)
Infertility is defined as the inability to conceive or carry a pregnancy to term after 24 months of trying to conceive. One half (50%) of infertility can be attributed to male factors, and about one half (50%) can be attributed to female factors. In some cases infertility can't be explained or is caused by a combination of factors in both partners.(More)
e19566 Background: The majority of patients with newly diagnosed stage IV cancer are vitamin D deficient at the time of diagnosis. We conducted a phase II trial to evaluate the efficacy and safety of oral supplementation with 25-hydroxyvitamin D3 [25(OH)D] in chemotherapy-naive patients. METHODS Eligibility critera included ECOG PS 0-3, low serum(More)
INTRODUCTION Early identification and management of chronic kidney disease (CKD) is highly cost-effective and can reduce the risk of kidney failure progression and cardiovascular disease. In 2014, the Joint Croatian Working Group (JCWG) for laboratory diagnostic of CKD on the behalf of Croatian society of medical biochemistry and laboratory medicine(More)
Haemoglobinopathies are hereditary disorders of globin chain synthesis and are the most common inherited diseases worldwide. Haemoglobin E is a structural haemoglobin variant characteristic for South East Asian population. We present a rare and unusual finding of haemoglobin E detected in University Hospital Centre Zagreb by capillary zone electrophoresis.(More)