Loren Niklason

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PURPOSE To assess cancer detection rates, false-positive rates before arbitration, positive predictive values for women recalled after arbitration, and the type of cancers detected with use of digital mammography alone and combined with tomosynthesis in a large prospective screening trial. MATERIALS AND METHODS A prospective, reader- and modality-balanced(More)
OBJECTIVES Reversal of the hematologic and visceral abnormalities characteristic of Gaucher disease, the most common lipid storage disorder, with biweekly infusions of macrophage-targeted glucocerebrosidase (glucosylceramidase) is well documented. The extent to which the skeleton responds to enzyme replacement therapy has not been systematically(More)
PURPOSE To compare radiologists' diagnostic accuracy and recall rates for breast tomosynthesis combined with digital mammography versus digital mammography alone. MATERIALS AND METHODS Institutional review board approval was obtained at each accruing institution. Participating women gave written informed consent. Mediolateral oblique and craniocaudal(More)
A method is described for using a limited number (typically 10-50) of low-dose radiographs to reconstruct the three-dimensional (3D) distribution of x-ray attenuation in the breast. The method uses x-ray cone-beam imaging, an electronic digital detector, and constrained nonlinear iterative computational techniques. Images are reconstructed with high(More)
PURPOSE To determine whether a lower radiation dose technique can be used for computed tomography (CT) of the pediatric pelvis without significant loss of diagnostic image quality. MATERIALS AND METHODS Thirty-six pediatric patients underwent CT at 80 mAs (experimental group), and 42 underwent CT at 240 mAs (control group). Anatomic details, image(More)
Interventional radiologists receive nonuniform occupational radiation doses, with relatively high doses to the head and extremities and low doses to the trunk, which is protected by a lead apron. Twenty-eight interventional radiologists from 17 institutions wore thermoluminescent dosimeters over their collars and under their aprons for a 2-month period. The(More)
Digital mammography systems allow manipulation of fine differences in image contrast by means of image processing algorithms. Different display algorithms have advantages and disadvantages for the specific tasks required in breast imaging-diagnosis and screening. Manual intensity windowing can produce digital mammograms very similar to standard screen-film(More)
Annual effective dose limits have been proposed by national and international radiation protection committees. Radiation protection agencies must decide upon a method of converting the radiation dose measured from dosimeters to an estimate of effective dose. A proposed method for the estimation of effective dose from the radiation dose to two dosimeters is(More)
PURPOSE To describe and evaluate a method of tomosynthesis breast imaging with a full-field digital mammographic system. MATERIALS AND METHODS In this tomosynthesis method, low-radiation-dose images were acquired as the x-ray source was moved in an arc above the stationary breast and digital detector. A step-and-expose method of imaging was used. Breast(More)
Mammography is an effective imaging tool for detecting breast cancer at an early stage and is the only screening modality proved to reduce mortality from breast cancer. However, the overlap of tissues depicted on mammograms may create significant obstacles to the detection and diagnosis of abnormalities. Diagnostic testing initiated because of a(More)