We constructed a transgenic mouse model that mimics the human autoimmune disease multiple sclerosis in its spontaneous induction and pathology. Transgenic mice were constructed expressing genes encoding a rearranged T cell receptor specific for myelin basic protein (MBP). T cell tolerance was not induced in the periphery, and functional, autoreactive T… (More)
have in common? Well, they are all Putnam Fellows. These are undergraduate students who have been ranked top 5 participants in the famous annual Putnam math competition in USA/Canada. All of them in this list are great problem solvers, and many of them have made significant contributions to cryptography (eg. Don Coppersmith's work on RSA via lattices-he was… (More)
We consider the pattern of zero and nonzero elements in the sequence Akb, where A is an n X n nonnegative matrix and b is an n X 1 nonnegative column vector. We establish a tight bound of k < n for the first occurrence of a given monomial pattern, and we give a graph theoretic characterization of triples (A, b, i) such that there exists a k, k ~ n, for… (More)
The members of the winning team were Nikifor C. Bliznashki, Jason Fer-guson, and Lingren Zhang; each was awarded a prize of $600.