Loren Allen Billings

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Metastatic melanoma cells express a number of protein tyrosine kinases (PTKs) that are considered to be targets for imatinib. We conducted a phase II trial of imatinib in patients with metastatic melanoma expressing at least one of these PTKs. Twenty-one patients whose tumours expressed at least one PTK (c-kit, platelet-derived growth factor receptors,(More)
7528 Background: Imatinib mesylate (Gleevec™), an oral inhibitor of phosphorylation of certain tyrosine kinases (TK), is active in gastrointestinal stromal tumors which are chemotherapy resistant. Perhaps MM may respond to Gleevec, especially if the tumor cells or microenvironment express one of the known TK targets: KIT, PDGF receptors α or β, c-abl, or(More)
Inflection class features that assign noun stems to declensional classes are peculiar objects. On the one hand, nominal inflection class features seem to be indispensable in analyses of noun inflection systems in various IndoEuropean languages (like Spanish, Greek, and Russian). On the other hand, nominal inflection class features differ from other,(More)
* I would like to thank Wyn Johnson for her detailed comments on the early drafts of this paper. and the audience in AFLA XII at UCLA, especially Loren Billings, Huang Huei-chuan, and Kie Zuraw, for their comments and suggestions, which have greatly improved the content of this paper. All errors made in this paper are my own responsibility. This paper is(More)
In planetary exploration and the search for life beyond Earth, the unique capabilities provided by human explorers will be advantageous to science only if the biological contamination associated with human presence is understood and controlled. The practice of preventing cross- contamination between the Earth and other planetary bodies is called planetary(More)
To determine whether texturing and coating have additive effects in promoting tissue integration and inhibiting fibrosis, we evaluated smooth silicone rubber (SSR), textured silicone rubber (TSR), porous silicone rubber (PSR), expanded polytetrafluoroethylene (ePTFE), and porous polyurethane (PPU) subcutaneous implants in eight minipigs. Some of the(More)
While the very real threats of language endangerment in the Philippines and elsewhere have motivated linguists to pursue a program of description, less attention has been granted to the documentation of rare storytelling traditions. Narrative Episodes from the Tulalang Epic provides material evidence of just how precious oral epics truly are, and why it is(More)
This study proposes an Optimality-theoretic model through which the various grammar components—semantics, syntax, the lexicon, morphology, and prosody—jointly determine the placement of clitics with a phrasal positioning domain, which is either a nominal expression or a clause. In order to render scope, such clitics must be phrase-initial. However, the(More)
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