Lorcan Browne

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Progressive multiple sclerosis is associated with metabolic failure of the axon and excitotoxicity that leads to chronic neurodegeneration. Global sodium-channel blockade causes side effects that can limit its use for neuroprotection in multiple sclerosis. Through selective targeting of drugs to lesions we aimed to improve the potential therapeutic window(More)
To deliver siRNA for therapeutic use, several hurdles must be addressed. Metabolic degradation must be blocked, and the RNAi cellular machinery is located in the cytoplasm, while double-stranded siRNA is large, highly charged and impermeable to cell membranes. To date, the solutions to the delivery issues have mostly involved different forms of lipid(More)
UNLABELLED Spiral ganglion neurons (SGNs) relay acoustic code from cochlear hair cells to the brainstem, and their stimulation enables electrical hearing via cochlear implants. Rapid adaptation, a mechanism that preserves temporal precision, and a prominent feature of auditory neurons, is regulated via dendrotoxin-sensitive low-threshold voltage-activated(More)
When filter-feeding shellfish are consumed raw, because of their ability to concentrate and store waterborne pathogens, they are being increasingly associated with human gastroenteritis and have become recognized as important pathogen vectors. In the shellfish industry, UV depuration procedures are mandatory to reduce pathogen levels prior to human(More)
A series of imidazol-1-ylethylindazole sodium channel ligands were developed and optimized for sodium channel inhibition and in vitro neuroprotective activity. The molecules exhibited displacement of a radiolabeled sodium channel ligand and selectivity for blockade of the inactivated state of cloned neuronal Nav channels. Metabolically stable analogue 6 was(More)
The performance of a 10 L sequencing batch reactor (SBR) treating wastewater discharged from a local slaughterhouse was examined in the laboratory at ambient temperature. The influent wastewater contained an average of 3360 mg L chemical oxygen demand (COD), 190 mg L total nitrogen (TN) and 22 mg L total phosphorus (TP). The duration of a complete cycle was(More)
Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis Sarah Al-Izki, Gareth Pryce, Deborah J.R. Hankey, Katie Lidster, Stephanie M. von Kutzleben, Lorcan Browne, Lisa Clutterbuck, Cristina Posada, A.W. Edith Chan, Sandra Amor, Victoria Perkins, Wouter H. Gerritsen, Kim Ummenthum, Regina Peferoen-Baert, Paul(More)
Journal of Medicinal Chemistry 2014, 57, 2942−2952. DOI: 10.1021/jm401881q Page 2944. In Table 1, “[H]sipatrigine” should read “[H]BW202W93”. Page 2944. In the right column lines 5 and 31, “[H]sipatrigine” should read “[H]BW202W93”. Page 2945. In Tables 2 and 3, “[H]sipatrigine” should read “[H]BW202W93”. Page 2946. In Table 4, “[H]sipatrigine” should read(More)
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