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GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity
Glutathione transferase Omega 1 (GSTO1-1) is an atypical GST reported to play a pro-inflammatory role in response to LPS. Here we show that genetic knockout of Gsto1 alters the response of mice to… Expand
Adenosine monophosphate deaminase 3 activation shortens erythrocyte half-life and provides malaria resistance in mice.
The factors that determine red blood cell (RBC) lifespan and the rate of RBC aging have not been fully elucidated. In several genetic conditions, including sickle cell disease, thalassemia, and G6PD… Expand
No evidence for genome editing in mouse zygotes and HEK293T human cell line using the DNA-guided Natronobacterium gregoryi Argonaute (NgAgo)
A recently published research article reported that the extreme halophile archaebacterium Natronobacterium gregoryi Argonaute enzyme (NgAgo) could cleave the cellular DNA under physiological… Expand
Four species of arboreal folivore show differential tolerance to a secondary metabolite
- Lora M. Jensen, I. Wallis, Karen J. Marsh, B. Moore, Natasha L. Wiggins, W. J. Foley
- Biology, Medicine
- 29 June 2014
The marsupials that eat Eucalyptus in south-eastern Australia provide an example of animals with similar niche requirements occurring sympatrically. They certainly differ in size, ranging from about… Expand
Proteases of human rhinovirus: role in infection.
Human rhinoviruses (HRV) are the major etiological agents of the common cold and asthma exacerbations, with significant worldwide health and economic impact. Although large-scale population… Expand
Rhinovirus 16 2A Protease Affects Nuclear Localization of 3CD during Infection
- E. Walker, Lora M. Jensen, +4 authors R. Ghildyal
- Biology, Medicine
- Journal of Virology
- 28 September 2016
ABSTRACT The human rhinovirus (HRV) 3C and 2A proteases (3Cpro and 2Apro, respectively) are critical in HRV infection, as they are required for viral polyprotein processing as well as proteolysing… Expand
The Relative Concentrations of Nutrients and Toxins Dictate Feeding by a Vertebrate Browser, the Greater Glider Petauroides volans
Although ecologists believe that vertebrate herbivores must select a diet that allows them to meet their nutritional requirements, while avoiding intoxication by plant secondary metabolites, this is… Expand
Variation in the nuclear effects of infection by different human rhinovirus serotypes
Human rhinovirus (HRV) is a positive sense RNA virus, which, despite replicating in the cytoplasm, has a significant impact on nuclear transport and nuclear localization of host proteins. A number of… Expand
Reverse genetic engineering of the human rhinovirus serotype 16 genome to introduce an antibody-detectable tag.
The ability to accurately detect viral proteins during infection is essential for virology research, and the lack of specific antibodies can make this detection difficult. Reverse genetic engineering… Expand
Effect of Rhinovirus Infection on the Host Apoptotic Response
The human rhinoviruses (HRV) are the most common viral cause of upper respiratory tract infections and are known to cause asthma exacerbations which may have serious consequences. One of the host’s… Expand