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Variation in the Glucose Transporter gene SLC2A2 is associated with glycaemic response to metformin
Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium reports a three-stageExpand
Phenotypic Tfh development promoted by CXCR5-controlled re-localization and IL-6 from radiation-resistant cells
TLDR
The results suggest that a Bcl6hiCXCR5hi phenotype does not automatically define a Tfh lineage but might reflect a state of antigen exposure and non-commitment to terminal effector fates and that niches in the T-B border and/or the follicle are important for optimal Bcl 6 induction and maintenance. Expand
Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center.
TLDR
An antigen-independent, contact-dependent, adhesive guidance system for TFH cells that regulates GC TFH recruitment and function and optimize antibody responses is defined. Expand
Recombinant Expression of a Novel Human Transcriptional Repressor HMBOX1 and Preparation of Anti-HMBOX1 Monoclonal Antibody
TLDR
It is identified that HMBOX1 is located in both cytoplasm and nucleus and could be detected in 10 human normal tissues, including cerebrum, pancreas, kidney and liver tissues, and the expression in hepatic carcinoma was significantly lower than that in adjacent tissues. Expand
HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway
TLDR
Overexpression of HMBOX1 significantly inhibited NK cell activities, including natural cytotoxicity against tumor cells, the level of CD107a (a marker protein for degranulation) and the production of cytolytic proteins (perforin and granzymes). Expand
SAP-Regulated T Cell–APC Adhesion and Ligation-Dependent and -Independent Ly108–CD3ζ Interactions
TLDR
It is shown that, other than phosphotyrosine-binding, SAP does not harbor motifs that recruit additional signaling intermediates to stabilize T–B adhesion, and new insights are offered into how SAP and Ly108 antagonistically modulate the strength of proximal TCR signaling and thereby control cognate T cell–APC interactions. Expand
HMBOX1, homeobox transcription factor, negatively regulates interferon-γ production in natural killer cells.
TLDR
It is found that the transcriptional levels of HMBOX1 were significantly decreased in NK cells after activated by IL-2, IL-15 and IL-12, which was opposite to the expression profile of IFN-γ. Expand
Tfh cell differentiation and their function in promoting B-cell responses.
TLDR
Follicular helper T cells are a newly defined helper T-cell subset that is specialized in facilitating B-cell responses and co-opting of the follicular program affords regulatory T cells, NK T cells and γδ T cells with opportunities to participate in the regulation of humoral immunity. Expand
NK cell-based approach for screening novel functional immune genes.
TLDR
An efficient method for the discovery of novel functional genes in NK cells by using an NK cell line as a screening platform is described and indicated that the two novel genes negatively influenced the cytotoxicity of NK-92 cells by inhibiting the expression of several activating receptors and immune functional genes. Expand
Identification of a new isoform of the murine Sh2d1a gene and its functional implications
TLDR
The functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability, andModulation of relative proportions of these isoforms is potentially a mechanism whereby cells can regulate SAP-mediated biological activities. Expand
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