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Microbial production of hyaluronic acid: current state, challenges, and perspectives
TLDR
This work summarizes the research history and current commercial market of HA, and deeply analyzes the current state of microbial production of HA by Streptococcus zooepidemicus and recombinant systems, and discusses the challenges facing microbial HA production and proposes several research outlines to meet the challenges. Expand
Optimization and scale-up of propionic acid production by propionic acid-tolerant Propionibacterium acidipropionici with glycerol as the carbon source.
TLDR
This glycerol feeding approach may be useful for propionic acid production on an industrial scale. Expand
Microbial production of propionic acid from propionibacteria: Current state, challenges and perspectives
TLDR
The integration of reverse metabolic engineering and systematic metabolic engineering provides an opportunity to significantly improve the acid tolerance of propionibacteria and reduce the formation of by-products, and makes it feasible to strengthen the commercial competition of biotechnological PA production from propionIBacteria to be comparable to the petrochemical route. Expand
Comparative genomics and transcriptome analysis of Aspergillus niger and metabolic engineering for citrate production
TLDR
Comparative genomics and transcriptome analysis of citrate-producing strains revealed that the transcription levels of 479 genes changed between the cell growth stage and the citrate synthesis stage, and two cytosol ATP-citrate lyases were up-regulated and may coordinate with the alternative oxidases in the alternative respiratory pathway for energy balance. Expand
Developing Bacillus spp. as a cell factory for production of microbial enzymes and industrially important biochemicals in the context of systems and synthetic biology
TLDR
The available genetic tools, engineering strategies, genome sequence, genome-scale structure models, proteome, and secretion pathways, and successful examples of enzymes and industrially important biochemicals produced by Bacillus spp. Expand
Systems-level understanding of how Propionibacterium acidipropionici respond to propionic acid stress at the microenvironment levels: mechanism and application.
TLDR
It was indicated that the acid tolerance of P. acidipropionici was systematically regulated, and the increased arginine, aspartic acid, and glutamic acid concentrations helped to resist the acidic environment by consuming more H⁺ and generating more ATP and NH₃. Expand
l-Amino acid oxidases from microbial sources: types, properties, functions, and applications
TLDR
The types, properties, structures, biological functions, heterologous expression, and applications of LAAOs obtained from microbial sources are reviewed to increase interest in LAAO studies. Expand
Modular pathway engineering of Bacillus subtilis for improved N-acetylglucosamine production.
TLDR
This work significantly enhanced GlcNAc production through modular pathway engineering of B. subtilis, and the engineering strategies used herein may be useful for the construction of versatile B.subilis cell factories for the production of other industrially important chemicals. Expand
Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: Advances and prospects.
TLDR
This review summarizes the synthesis pathways of these organic acids in the TCA cycle and proposes further improvements for the production of organic acids with systems and synthetic biology-guided metabolic engineering strategies. Expand
Structure-based engineering of histidine residues in the catalytic domain of α-amylase from Bacillus subtilis for improved protein stability and catalytic efficiency under acidic conditions.
TLDR
This work provides an effective strategy to improve the catalytic activity and stability of α-amylase under acidic conditions, and the results obtained here may be useful for the improvement of acid-resistant ability of other enzymes. Expand
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