Long Green

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Current concepts in gene transfer and its application to the treatment of human genetic disorders, cancer, and other diseases are discussed. Gene therapy is a technique in which a functioning gene is inserted into a human cell to correct a genetic error or to introduce a new function to the cell. Many methods, including retroviral vectors, have been(More)
Since the first demonstrations of the herbicidal action of 2,4-D, many possible mechanisms for the toxicity have been proposed. These include changed respiratory metabolism, abnormal cellular proliferation, and interference in nucleotide metabolism. It has further been recorded that nitrate metabolism is altered in response to applied 2,4-D. In many broad(More)
Guidelines for describing cancer chemotherapy regimens in all aspects of drug development, including treatment protocols, order forms, and product labels, are proposed. To complement the approaches to reducing medication errors that have been recommended by ASHP and others, pharmacists at the National Institutes of Health and the National Cancer Institute,(More)
Atopic dermatitis (AD) is defined as a genetically predisposed inflammatory and pruritic allergic skin disease with characteristic clinical features associated with IgE antibodies most commonly directed against environmental allergens 1 . Given how complex and poorly understood the pathogenesis and causes of AD are in humans and animals, the specifics of(More)
The study of dermatologic diseases in nonhuman primates (NHP) has been neglected almost entirely by veterinary dermatologists. The scientific literature regarding this subject is disparate and unorganized. In “Nonhuman primate dermatology: a literature review” in 2009, this author attempted to gather wide-ranging case reports and studies into a more(More)
Policies and procedures for handling gene-transfer products at the National Institutes of Health (NIH) Clinical Center pharmacy department are described. The pharmacy at the Clinical Center is responsible for handling in vivo gene-transfer delivery systems, which are gene-transfer products that are prepared for direct administration to patients. The(More)
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