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We present several mesh smoothing schemes based on the concept of optimal Delaunay triangulations. We define the optimal Delaunay triangulation (ODT) as the triangulation that minimizes the interpolation error among all triangulations with the same number of vertices. ODTs aim to equidistribute the edge length under a new metric related to the Hessian(More)
A widely used electrostatics model in the biomolecular modeling community, the nonlinear Poisson–Boltzmann equation, along with its finite element approximation, are analyzed in this paper. A regularized Poisson–Boltzmann equation is introduced as an auxiliary problem, making it possible to study the original nonlinear equation with delta distribution(More)
The N-methyl-D-aspartate (NMDA) receptor (NMDA-R) has pivotal roles in neural development, learning, memory, and synaptic plasticity. Functional impairment of NMDA-R has been implicated in schizophrenia. NMDA-R activation requires glycine to act on the glycine-B (GlyB) site of the NMDA-R as an obligatory co-agonist with glutamate. Extracellular glycine near(More)
The atypical antipsychotic drug clozapine effectively alleviates both negative and positive symptoms of schizophrenia via unclear cellular mechanisms. Clozapine may modulate both glutamatergic and dopaminergic transmission in the prefrontal cortex (PFC) to achieve part of its therapeutic actions. Using whole cell patch-clamp techniques, current-clamp(More)
Olmsted syndrome (OS) is a rare congenital disorder characterized by palmoplantar and periorificial keratoderma, alopecia in most cases, and severe itching. The genetic basis for OS remained unidentified. Using whole-exome sequencing of case-parents trios, we have identified a de novo missense mutation in TRPV3 that produces p.Gly573Ser in an individual(More)
The computational power provided by many-core graphics processing units (GPUs) has been exploited in many applications. The programming techniques currently employed on these GPUs are not sufficient to address problems exhibiting irregular, and unbalanced workload. The problem is exacerbated when trying to effectively exploit multiple GPUs concurrently,(More)
PURPOSE To identify risk factors relevant to radiation-induced liver disease (RILD) and to determine the hepatic tolerance to radiation. METHODS AND MATERIALS The data of 109 primary liver carcinomas (PLC) treated with hypofractionated three-dimensional conformal radiation therapy (3D-CRT) were analyzed. Seventeen patients were diagnosed with RILD and 13(More)
BACKGROUND Spontaneous low-frequency fluctuations (LFF) in the blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal have been shown to reflect cerebral spontaneous neural activity, and the present study attempts to explore the functional changes in the regional brain in patients with schizophrenia using the amplitude of(More)
The convergence and optimality of adaptive mixed finite element methods for the Poisson equation are established in this paper. The main difficulty for mixed finite element methods is the lack of minimization principle and thus the failure of orthogonality. A quasi-orthogonality property is proved using the fact that the error is orthogonal to the(More)
Hashing, a basic tool in computer forensics, is used to ensure data integrity and to identify known data objects efficiently. Unfortunately, intentional tiny modified file can not be identified using this traditional technique. Context triggered piecewise hashing separates a file into pieces using local context characteristic, and produces a hash sequence(More)