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The arachidonic acid metabolizing CYP enzymes with prominent roles in vascular regulation are epoxygenases of the two gene family which generate epoxyeicosatrienoic acids. Carriers of CYP2C9 mutant alleles exhibit a diminished CYP2C9 metabolic capacity leading to decreased endothelium-derived hyperpolarizing factors (EDHF) synthesis and an increased risk(More)
PURPOSE In the present study, we aimed to investigate the changes in plasma miRNA in patients with wet age-related macular degeneration. METHODS The expression profiles of 384 miRNAs in plasma from 33 patients (22 male, 11 female) who were diagnosed with wet age-related macular degeneration with fundus examination, fundus fluorescein angiography, and(More)
Altered microRNA (miRNA) expression has been found in many cancers, including lung, breast, prostate, bladder and colorectal cancer. Many recent studies have demonstrated that aberrant plasma miRNAs were also found in various types of cancers. However, the alteration in plasma miRNA expressions in laryngeal squamous cell carcinoma (LSCC) remains unclear.(More)
Our study aimed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) by comparing its biochemical effects with those of WR-2721, as a representative of clinically used radioprotectors, in preventing oxidative damage caused by gamma irradiation (single dose, 6Gy) in normal rat tissue. The rats (n=40) were divided randomly and(More)
Pancreatic cancer has been linked with exposure to environmental chemicals, which generally require metabolic activation to highly reactive toxic or carcinogenic intermediates. N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) are expressed primarily in extrahepatic and hepatic tissues, respectively. Both enzymes catalyze N- and O-acetylation of(More)
Peroxynitrite is involved in the pathogenesis of pulmonary diseases such as asthma, occupational pulmonary diseases and acute respiratory distress syndrome (ARDS) due to excessive production of nitric oxide or superoxide or both. Lornoxicam, a new oxicam derivative, is a potent anti-inflammatory agent. In this study, we evaluated the role of lornoxicam in a(More)
1Department of Obstetrics and Gynecology, Faculty of Medicine, Mersin University, Mersin, Turkey 2Department of Internal Medicine, Faculty of Medicine, Mersin University, Mersin, Turkey 3Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey 4Department of Biochemistry, Faculty of Medicine, Mersin University,(More)
BACKGROUND microRNAs (miRNAs) are single-stranded, noncoding RNA molecules. Given the vast regulatory potential of miRNAs and their often tissue-specific and disease-specific expression patterns, miRNAs are being assessed as possible biomarkers to aid diagnosis and prediction of different types and stages of cancers, including skin cancer. Basal cell(More)
AIM To investigate the association of CYP2C19 genotypes with endometriosis. METHODS The study included 100 women who underwent laparotomy or laparoscopy: 50 patients with endometriosis diagnosed with surgery and histopathology, and 50 control subjects who had no evidence of endometriosis during exploratory laparotomy or laparoscopy. Genomic DNA of(More)
Thirty-two adult Wistar-Albino female and male rats were used to investigate the long-term (45 days) effects of extremely low frequency magnetic field (ELF-MF; 50Hz, 1mT, 4h/day) exposure on oxidative/nitrosative stress in liver tissues of rats. The rats were divided randomly into four groups: female control (FC; n = 8) and MF-exposed female rats (F-MF; n =(More)