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The Rat Genome Database (RGD, http://rgd.mcw.edu) is an NIH-funded project whose stated mission is 'to collect, consolidate and integrate data generated from ongoing rat genetic and genomic research efforts and make these data widely available to the scientific community'. In a collaboration between the Bioinformatics Research Center at the Medical College(More)
Keratins are intermediate filament-forming proteins that provide mechanical support and fulfill a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to name the keratin proteins that were known at that point. The systematic sequencing of the human genome in recent years uncovered the existence of several novel keratin(More)
The ARID is an ancient DNA-binding domain that is conserved throughout the evolution of higher eukaryotes. The ARID consensus sequence spans about 100 amino acid residues, and structural studies identify the major groove contact site as a modified helix-turn-helix motif. ARID-containing proteins exhibit a range of cellular functions, including participation(More)
Nucleic acid helicases are characterized by the presence of the helicase domain containing eight motifs. The sequence of the helicase domain is used to classify helicases into families. To identify members of the DEAD and DEAH families of human RNA helicases, we used the helicase domain sequences to search the nonredundant peptide sequence database. We(More)
  • Jürgen Schweizer, Paul E Bowden, Lois Maltais, M Bishr Omary, David A D Parry, Michael A Rogers +1 other
  • 2006
What's in a name? That which we call a rose, by any other name would smell as sweet (Romeo and Juliet, Act II, Sc. ii). Keratins (previously also called cytokeratins) are fi lament-forming proteins of epithelial cells and are essential for normal tissue structure and function. Keratin genes account for most of the intermediate fi lament genes in the human(More)
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