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  • Laurent Salphati, Xiaoyan Chu, +17 authors N Scheer
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 August 2014
  • Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. DetailedContinue Reading
  • Gisela Backfisch, Beate Reder-Hilz, +4 authors Michael Schulz
  • Chemistry, Medicine
  • Bioanalysis
  • 1 April 2015
  • BACKGROUND Metabolite identification studies are very resource intensive and also are rarely performed in early discovery. Here, we report the validation of an ultraperformance liquidContinue Reading
  • Alison Margolskee, Adam S Darwich, +55 authors Bertil Abrahamsson
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 2017
  • &NA; Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development. Physiologically‐based pharmacokineticContinue Reading
  • Alison Margolskee, Adam S Darwich, +44 authors Bertil Abrahamsson
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 2017
  • &NA; Predicting oral bioavailability (Foral) is of importance for estimating systemic exposure of orally administered drugs. Physiologically‐based pharmacokinetic (PBPK) modelling and simulation haveContinue Reading
  • Dominik Gartzke, Juergen Delzer, +6 authors Gert Fricker
  • Chemistry, Medicine
  • Pharmaceutical Research
  • 1 June 2015
  • PurposeTo investigate whether it is possible to specifically suppress the expression and function of endogenous canine P-glycoprotein (cPgp) in Madin-Darby canine kidney type II cells (MDCKII)Continue Reading
  • Diana Clausznitzer, César Pichardo-Almarza, +5 authors Marjoleen Nijsen
  • Medicine
  • CPT: pharmacometrics & systems pharmacology
  • 1 November 2018
  • Alzheimer disease (AD) is a devastating neurodegenerative disorder with high unmet medical need. Drug development is hampered by limited understanding of the disease and its driving factors.Continue Reading