• Citations Per Year
Learn More
High throughput drug screening has become a critical component of the drug discovery process. The screening of libraries containing hundreds of thousands of compounds has resulted in a requirement for assays and instrumentation that are amenable to nonradioactive formats and that can be miniaturized. Homogeneous assays that minimize upstream automation of(More)
Double-stranded (ds)’ DNA, which is the stable form of most DNA in vivo, must become partially unwound (non-base paired), at least transiently, to form the single-stranded (ss) DNA intermediates required for DNA replication, recombination, and repair. A class of enzymes called DNA helicases2 functions at s ~ / ds-DNA junctions (e.g. replication forks) to(More)
  • 1