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BACKGROUND Breast carcinoma is a disease with a tremendous heterogeneity in its clinical behavior. Newer prognostic factors and predictors of response to therapy are needed. The aim of this study was to evaluate the expression of HER-2, estrogen receptor (ER) and progesterone receptors (PR) in breast carcinoma and to compare it with other prognostic(More)
BACKGROUND Testicular lymphoma is a lethal disease with a median survival of approximately 12 to 24 months. Nasal-type natural killer/T-cell lymphoma of the testis is exceptional whether as a primary or secondary tumor. AIM The authors report on the comprehensive histopathologic, immunohistochemical and molecular analysis of a case of primary testicular(More)
Dear Editor, Lipofibromatosis is a rare, recently reported, fibrofatty pediatric tumor, which affects mainly extremities [1, 6]. Histopathological features of this tumor must be distinguished from fibrous hamartoma of child, fibromatosis, calcifying aponevrotic fibroma, and lipoblastoma [1]. Pigmented lipofibromatosis is a rare histological variant of(More)
The methylation of CpG islands in the promoters is associated with loss of protein via repression of gene transcription. Several studies have demonstrated that tumour suppressor and DNA repair genes are often aberrantly hypermethylated in colorectal cancer. The present study was conducted to examine whether the methylation profile of p16INK4a and hMLH1(More)
The granular cell tumor (GCT) or Abrikossoff tumor is a neurogenic tumor often benign with a predominant cervicofacial localization. The mean age of onset ranges between 40 and 60 years of age. Female patients are twice more affected. It is a rare tumor (0.019 to 0.03% of all tumors). The prognosis is usually favorable after surgical excision. The(More)
Pulmonary oxalosis is a very rare pseudotumoral lesion; it is often secondary to an aspergillus infection. Oxalic acid (C(2)H(2)O(4)) is a mycotoxin released by Aspergillus niger and sometimes by several other fungi, including A flavus and A fumigatus. We report a case of a 69 year old man, with previous history of pulmonary tuberculosis, followed for(More)
BACKGROUND Dermatofibroma represents one of the commonest benign soft tissue tumours, and its diagnosis is usually straightforward if classical clinicopathologic features are evident. It occurs frequently on the extremities and trunk, often in young adults during the 3(rd) and 4(th) decades. We report a peculiar case of an aggressive cellular dermatofibroma(More)
INTRODUCTION Basosquamous carcinoma is a rare entity that essentially affects the head and neck region in male patients. The authors present the clinical signs and progression as well as the therapeutic consequences of this disease through two observations. CASE REPORT 1: A 41-year-old man presented with basosquamous carcinoma of the right temporoparietal(More)
Gliosarcoma is a rare, malignant, biphasic brain tumor formed by both glioblastoma and sarcomatous components. Various lines of differentiation are described in the latter component, but most commonly fibrosarcomatous and pleomophic sarcoma are present. Osteosarcomatous features are exceedingly rare. We report a case of gliosarcoma with osteosarcomatous(More)