AIMS
The purpose of this human intestinal perfusion study was to investigate the effect of ketoconazole on the jejunal permeability and first-pass metabolism of (R)- and (S)-verapamil in humans.
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OBJECTIVES
The primary objective was to investigate the effective permeability and the hepatic extraction of fluvastatin, a new 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor,… (More)
Previous studies of mast-cell density and histamine content in biopsy specimens in patients with Crohn's disease have yielded conflicting results. In this in vivo study we have measured the jejunal… (More)
The mechanisms controlling rates and routes for intestinal absorption of nutrients and small compounds are still not fully clarified. In the present study we aimed to investigate the effect of… (More)
Patients with Crohn's disease of the distal ileum show increased permeability to hyaluronan and increased release of histamine and complement components in uninvolved parts of the proximal jejunum.… (More)
Sciomyzid flies, which have potential as bio-indicators, were sampled by sweep-net surveys at a turlough in the west of Ireland. Turloughs are ephemeral wetlands (unique to Ireland), which flood from… (More)
The biology of snail-killing flies (Diptera: Sciomyzidae) has been studied intensively over the past half-century, especially over the past decade. Today, sciomyzids are biologically the best-known… (More)
A low pH in the lumen of the stomach and duodenum stimulates gastroduodenal mucosal secretion of bicarbonate, particularly in the duodenum. Long-term deprivation of this acid stimulus might affect… (More)
The object of this study was to determine if brain computed tomography (CT) scan measures are related to treatment response to clozapine, an atypical antipsychotic drug that is effective in some… (More)