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  • Lloyd Paul Aiello, Robert L. Avery, +7 authors J. E. Park
  • Medicine
  • The New England journal of medicine
  • 1994 (First Publication: 1 December 1994)
  • BACKGROUND Retinal ischemia induces intraocular neovascularization, which often leads to glaucoma, vitreous hemorrhage, and retinal detachment, presumably by stimulating the release of angiogenicContinue Reading
  • Erin Pierce, Robert L. Avery, E D Foley, Lloyd Paul Aiello, Lois E. H. Smith
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1995 (First Publication: 31 January 1995)
  • Neovascular diseases of the retina are a major cause of blindness worldwide. Hypoxia is thought to be a common precursor to neovascularization in many retinal diseases, but the factors involved inContinue Reading
  • Lloyd Paul Aiello, Erin Pierce, +6 authors Lois E. H. Smith
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1995 (First Publication: 7 November 1995)
  • The majority of severe visual loss in the United States results from complications associated with retinal neovascularization in patients with ischemic ocular diseases such as diabetic retinopathy,Continue Reading
  • Pu Xia, Lloyd Paul Aiello, +7 authors George L King
  • Medicine
  • The Journal of clinical investigation
  • 1996 (First Publication: 1 November 1996)
  • Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen which mediates its effects by binding to tyrosine kinase receptors. We have characterized the VEGF-activatedContinue Reading
  • Emmett T Cunningham, Anthony P. Adamis, +8 authors Steven D. Schwartz
  • Medicine
  • Ophthalmology
  • 2005 (First Publication: 1 October 2005)
  • OBJECTIVE To evaluate the safety and efficacy of pegaptanib sodium injection (pegaptanib) in the treatment of diabetic macular edema (DME). DESIGN Randomized, double-masked, multicenter,Continue Reading
  • Lloyd Paul Aiello, Sven E Bursell, +9 authors George L King
  • Medicine
  • Diabetes
  • 1997 (First Publication: 1 May 1998)
  • Increased vascular permeability and excessive neovascularization are the hallmarks of endothelial dysfunction, which can lead to diabetic macular edema and proliferative diabetic retinopathy in theContinue Reading