Lloyd E. King

Kathleen A. Silva6
Helen B. Everts3
F. Jason Duncan2
Kevin J. McElwee2
6Kathleen A. Silva
3Helen B. Everts
2F. Jason Duncan
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Elevated expression of matrix metalloproteinase-3 (MMP-3/stromelysin-1) is associated with a variety of tumor types, although its in vivo functional role remains unclear. In human and murine squamous cell carcinoma (SCC), MMP-3 is expressed in the stromal compartment at all of the stages of tumor progression and is expressed by the malignant epithelial(More)
Alopecia areata (AA) is an autoimmune disease that attacks anagen hair follicles. Gene array in graft-induced C3H/HeJ mice revealed that genes involved in retinoic acid (RA) synthesis were increased, whereas RA degradation genes were decreased in AA compared with sham controls. This was confirmed by immunohistochemistry in biopsies from patients with AA and(More)
C57BL/6 mice develop dermatitis and scarring alopecia resembling human cicatricial alopecias (CAs), particularly the central centrifugal CA (CCCA) type. To evaluate the role of retinoids in CA, the expression of retinoid metabolism components were examined in these mice with mild, moderate, or severe CA compared with hair cycle-matched mice with no disease.(More)
There is increasing awareness of the role of mtDNA alterations in the development of cancer, as mtDNA point mutations are found at high frequency in a variety of human tumors. To determine the biological effects of mtDNA mutations in UV-induced skin tumors, hairless mice were irradiated to produce tumors, and the tumor mtDNAs were screened for(More)
BACKGROUND There have been repeated initiatives to produce standard nosologies and terminologies for cutaneous disease, some dedicated to the domain and some part of bigger terminologies such as ICD-10. Recently, formally structured terminologies, ontologies, have been widely developed in many areas of biomedical research. Primarily, these address the aim(More)
Alopecia areata (AA), the second most common form of hair loss in humans, is characterized by waxing and waning focal hair loss. Alopecic foci can expand to encompass the entire head (alopecia totalis) or body (alopecia universalis, AU). This cell mediated autoimmune disease is characterized histologically by the " swarm of bees " , CD4 + and CD8 + T cells,(More)
To the editor The proceedings of a recent meeting on alopecia areata (AA) (Bertolini et al., 2012) summarized work using the surgically induced C3H/HeJ mouse model for AA (McElwee et al., 1998), in which investigators found enlarged hearts in affected mice, suggesting an association between AA and cardiac findings. However, the heart lesions described are a(More)
Mice. C3H/HeJ +/+ (JR# 659) inbred mice were obtained from The Jackson Laboratory (Bar Harbor, ME). Mice were maintained in a humidity-, temperature-, and light cycle (12:12) controlled vivarium under specific pathogen-free conditions housed in double-pen polycarbonate cages (330 cm 2 floor area) at a maximum capacity of four mice per pen. Mice were allowed(More)
Rodent models with autoimmune diseases provide many insights to unravel the complexities of human diseases as tools for hypothesis testing and preclinical drug efficacy screening (Sun et al., 2008). Nearly ten years ago, we performed a comparative mouse and human gene array study to identify potentially dysregulated genes in alopecia areata (AA). One such(More)
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