Ljubov Mikhailova

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Teraphtal-Lio (Tph) exerted a toxic dose-dependent effect on the hemostatic system. Treatment of experimental animals with maximum tolerated and highly toxic doses was followed by acute DVS syndrome formation involving a hemophilic condition, soaring activated partial prothrombin time, absence of fibrinogen, sharp rise in fibrinogen degradation product and(More)
Pre-clinical toxicologic studies were conducted of a new drug teraphtal-Lio (TPh) and a teraphtal-Lio + ascorbic acid (TPh + AA) catalytic system recommended for binary catalytic therapy of malignant tumors. Quantitative criteria for "acute" and "chronic" toxicity of TPh and TPh + AA were established, which describe their toxic effects in single or multiple(More)
A binary teraphtal-Lio + ascorbic acid (Tph + AA) catalytic system has been tested for untoward side-effects using three procedures of regional intraarterial infusion on dogs. On the basis of the data on local-tissue and overall toxicity, an optimal one was selected and recommended for clinical use.
Effects of ADP and Mg2+ on the ability of cyclosporin A to "reseal" mitochondria permeabilized by Ca2+ and P(i) have been studied. Cyclosporin A was completely ineffective, when ADP and Mg2+ were not included into the incubation medium. Both ADP and Mg2+ used at high concentrations potentiated the effect of cyclosporin A and prevented it reversal by(More)
Earlier it has been demonstrated that the recoupling action of cyclosporin A on mitochondria deenergized by the opening of the Ca(+)-dependent pore requires higher cyclosporin A concentrations than those, which are necessary for preventing the permeabilization as well as the presence of additional effectors, such as adenine nucleotides and Mg2+. It has been(More)
A brief survey of disseminated intravascular coagulation (DIC) is presented, with clinical, paraclinical and pathologoanatomical characteristic. The difficulties in making the diagnosis at the clinic are stressed upon, authors' observations on one male subject, admitted to the clinic with multiple extensive subcutaneous hemorrhages are reported, that were(More)
Study of tumorigenic activity of cultured human chondroblasts intended for autologous transplantations showed that subcutaneous injection of human chondroblast suspension in a dose of 10(7)cells/0.2 ml did not cause the development of tumors in C.B-17 SCID immunodeficient mice over 12 weeks. Subcutaneous formations of compact cartilaginous consistency(More)