Ljuba Bacharova

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BACKGROUND The electrocardiographic (ECG) diagnosis of left ventricular hypertrophy (LVH) is based on the assumption that QRS voltage increases with left ventricular mass. However, most of patients with echocardiographically detected LVH do not have increased QRS voltage. Reduced intercellular coupling has been observed in LVH patients and animal models.(More)
cardiac myocytes under physiological conditions, are described as planar waves traveling along the longitudinal cell axis [1]. Other patterns of Ca 2+ wave propagation – circular or spiral Ca 2+ waves [2, 3] – have been observed in physiological conditions as well. have described spiral calcium waves as individual events. We demonstrate hereby existence of(More)
1 Condensed Abstract We simulated myocardial uncoupling with and without disruption of the left bundle branch using a realistic large-scale computer model. Both caused left axis deviation in the ECG but uncoupling reduced amplitude while bundle branch disruption increased it. Their combination can explain a left bundle branch block ECG with low amplitude. 2(More)
The traditional approach to the ECG diagnosis of left ventricular hypertrophy (LVH) is focused on the best estimation of left ventricular mass (LVM) i.e. finding ECG criteria that agree with LVM as detected by imaging. However, it has been consistently reported that the magnitude of agreement is rather low as reflected in the low sensitivity of ECG(More)
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