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We performed rapid sequential CT scanning following iv injection of a bolus of contrast medium and generated three functional images relating to intravascular circulation time (rABCT), vascular volume (Vv) density and blood-brain barrier (BBB) unidirectional constant uptake rate (Ki), respectively. This was accomplished by calculating the first mathematical(More)
We performed angio-CT following i.v. administration of an iodinated contrast medium and analyzed the pixel contrast time-density curves from 4 to 10 min postinjection to derive vascular and volume BBB permeability images. This was performed by applying multiple regression analysis of pixel contrast curves versus blood contrast and integrated blood contrast(More)
OBJECTIVE To investigate the relationship between awareness of memory loss and psychological well-being in a nonclinically depressed sample of participants with mild to moderate Alzheimer disease (AD). METHODS Study participants (N = 104) enrolled through Columbia University Medical Center and the University of Pennsylvania completed clinical and(More)
We analyzed the possibility of assessing functional vasomotor changes by means of Arm-Brain Circulation Time (rABCT) and Vascular volume images (Vv) obtained with Angio-CT, in basal condition and following CO2 inhalation, in a sample of 48 patients with cluster headache. CO2 inhalation resulted in the appearance of local changes, which were detected in 28(More)
We performed rapid sequential computerized tomography (CT) scanning following i.v. injection of a bolus of contrast medium, and generated three functional images related, respectively, to intravascular circulation time (rABCT), vascular volume density (Vv) and blood-brain barrier (BBB) unidirectional constant uptake rate (Ki). This was accomplished by(More)
We derived rCBF (ND-rCBF) images using non-diffusible contrast agent time-density curves obtained by monitoring the first pass with an angio-CT sequence. An appropriate elaboration of the sequence of the images led to the generation of vascular volume (Vv) and regional Arm-Brain circulation time images (rABCT). ND-rCBF was obtained by dividing the Vv image(More)
We analyzed circulation time (rABCT) and vascular volume density images obtained by angio-computerized tomography (angio-CT) in 63 patients with small deep cerebral infarctions. Abnormalities in the rABCT image were found in 88% of the patients and in the vascular volume image in 48%. Two groups with different clinical pictures were picked out by rABCT(More)
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