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Information sharing among distributed obsolescence management systems is a challenge because of the heterogeneity of data (data with different forms and representations). Indeed, this is the main hurdle that exists for current tools managing product obsolescence. This paper presents a hybrid ontology approach for the integration of obsolescence information(More)
Hepatitis B virus (HBV) infection has persisted as a major public health problem due to the lack of an effective treatment for those chronically infected. Therapeutic vaccination holds promise, and targeting HBV polymerase is pivotal for viral eradication. In this research, a computational approach was employed to predict suitable HBV polymerase targeting(More)
Increased plasma levels of bilirubin have been reported in rat models and patients with alcoholic liver disease (ALD). The constitutive androstane receptor (CAR) is a known xenobiotic receptor, which induces the detoxification and transport of bilirubin. In the present study, the bilirubin transport regulatory mechanisms, and the role of CAR activation in(More)
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