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Genes are packaged into nucleosomal arrays, each nucleosome typically having two copies of histones H2A, H2B, H3, and H4. Histones have distinct posttranslational modifications, variant isoforms, and dynamics. Whether each histone copy within a nucleosome has distinct properties, particularly in relation to the direction of transcription, is unknown. Here(More)
A subset of Non-Small Cell Lung Carcinoma (NSCLC) carries chromosomal rearrangements involving the Anaplastic Lymphoma Kinase (ALK) gene. ALK-rearranged NSCLC are typically adenocarcinoma characterized by a solid signet-ring cell pattern that is frequently associated with a metastatic phenotype. Recent reports linked the presence of ALK rearrangement to an(More)
RNA editing is a molecular event that alters specific nucleotides in RNA post-transcriptionally. RNA editing has the potential to impact a variety of cellular processes and is implicated in diseases such as cancer. Yet, the precise mechanisms by which RNA editing controls cellular processes are poorly understood. Here, we characterize sequences altered by(More)
In order to realize the rapid deployment of indoor localization systems, the crowdsourcing method has been proposed to reduce the collection workload. However, compared to conventional methods, the reduced number of received signal strength (RSS) values lends greater influence to noises and erroneous measurements in RSS values. In this paper, a graph-based(More)
A method combining machine learning and regression analysis to automatically and intelligently update predictive models used in the Kansas Department of Transportation's (KDOT's) internal management system is presented. The predictive models used by KDOT consist of planning factors (mathematical functions) and base quantities (constants). The duration of a(More)
Modern technologies such as GIS, remote sensing technology, traffic simulation technology and intelligent transportation system are developing rapidly, which have deeply changed the traffic behaviors. In order to meet the quick changing in transportation and use the emerging new technologies, the transportation planning system should have flexible(More)
Evolutionary forces resulted from competitions between different populations are common, which change the evolutionary behavior of a single population. In an isolated population of coordination games of two strategies (e.g., s_{1} and s_{2}), the previous studies focused on determining the fixation probability that the system is occupied by only one(More)
The clinical importance of anterior foregut endoderm (AFE) derivatives, such as thyrocytes, has led to intense research efforts for their derivation through directed differentiation of pluripotent stem cells (PSCs). Here, we identify transient overexpression of the transcription factor (TF) NKX2-1 as a powerful inductive signal for the robust derivation of(More)
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