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The FGFR3 mutation is related to favorable pT1 bladder cancer.
Prognostic value of molecular markers, sub‐stage and European Organisation for the Research and Treatment of Cancer risk scores in primary T1 bladder cancer
Study Type – Prognosis (case series)
Correlation of ERG Expression and DNA Methylation Biomarkers with Adverse Clinicopathologic Features of Prostate Cancer
CYP26A1, TBX15, and HOXD3 are methylation markers of prostate cancer associated with ERG expression and clinicopathologic variables, suggesting that incorporation of these markers may be useful in a pre- and posttreatment clinical setting.
Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression
It is demonstrated that quantitative increase in promoter methylation levels of APC, HOXD3 and TGFβ2 are associated with PCa progression, and quantitative methylation assessment of a multiplex panel of markers outperforms any single marker for the prediction of biochemical recurrence.
DNA methylation of HOXD3 as a marker of prostate cancer progression
The results indicate that HOXD3 methylation distinguishes low-grade prostate cancers from intermediate and high-grade ones and may also have prognostic value when considered together with pathological stage.
FGFR3 mutations, but not FGFR3 expression and FGFR3 copy-number variations, are associated with favourable non-muscle invasive bladder cancer
FGFR3 wild-type tumours with over-expression of the protein may still represent a subset of patients originally diagnosed as T1 BC that might potentially benefit from FGFR3-targeted therapy.
Molecular and clinical support for a four-tiered grading system for bladder cancer based on the WHO 1973 and 2004 classifications
Clinical validation showed that the two classification systems were both significant predictors for progression but not for recurrence, and results support a four-tiered grading system using the 1973 and 2004 WHO classifications with one low-grade (LMP/LG/G1) category that includes LMP, two intermediate grade (LG/ G2 and HG/G2) categories and one high- grade (HG/G3) category.
Distinct DNA methylation alterations are associated with cribriform architecture and intraductal carcinoma in Gleason pattern 4 prostate tumors.
To the best of the authors' knowledge, this provides the first evidence for an association between cribriform and/or IDC and methylation biomarkers, and warrants further investigation of additional DNA methylation events in association with various architectural patterns in prostate cancer.
Quantitative Estimation of Oxidative Stress in Cancer Tissue Cells Through Gene Expression Data Analyses
A computational method is presented for predicting the quantitative level of the intracellular oxidative stress in cancer tissue cells and the validity of the predictor is assessed by assessing it against genes that are known to have anti-oxidative functions for specific types of oxidative stressors.
Prognostic Role of MicroRNA-497 In Cancer Patients: A Meta-analysis
High expressing levels of miR-497 might be a potential biomarker which can be used to predict the better prognosis of different cancer types.