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Spreadsheet languages, which include commercial spreadsheets and various research systems, have had a substantial impact on end-user computing. Research shows, however, that spreadsheets often contain faults; thus, we would like to provide at least some of the benefits of formal testing methodologies to the creators of spreadsheets. This article presents a(More)
Transcription activator-like effectors (TALEs) can be used as DNA-targeting modules by engineering their repeat domains to dictate user-selected sequence specificity. TALEs have been shown to function as site-specific transcriptional activators in a variety of cell types and organisms. TALE nucleases (TALENs), generated by fusing the FokI cleavage domain to(More)
Form-based visual programming languages, which include electronic spreadsheets and a variety of research systems , have had a substantial impact on end-user computing. Research shows that form-based visual programs often contain faults, and that their creators often have unwarranted confidence in the reliability of their programs. Despite this evidence, we(More)
Form-based visual programming languages, which include commercial spreadsheets and various research systems , have had a substantial impact on end-user computing. Research shows, however, that form-based visual programs often contain faults. We would like to provide at least some of the beneets of formal testing methodologies to the creators of these(More)
This paper considers a set of ozone data in the conter-minous U.S., which records the ozone concentration levels at a set of monitoring sites during 1994 and 1999. Existing GIS techniques are insufficient in handling such kind of spatiotemporal data in terms of data interpolation, visual-ization, representation and querying. We adopt 3-D shape functions(More)
This paper investigates spatiotemporal interpolation methods for the application of air pollution assessment. The air pollutant of interest in this paper is fine particulate matter PM2.5. The choice of the time scale is investigated when applying the shape function-based method. It is found that the measurement scale of the time dimension has an impact on(More)
Several lines of evidence suggest involvement of NMDA receptors (NMDARs) in the regulation of neurogenesis in adults and the formation of spatial memory. Functional properties of NMDARs are strongly influenced by the type of NR2 subunits incorporated. In adult forebrain regions such as the hippocampus and cortex, only NR2A and NR2B subunits are available to(More)
We consider spatio-temporal interpolation of geographic data using both the reduction method, which treats time as an independent dimension, and the extension method, which treats time as equivalent to a spatial dimension. We adopt both 2-D and 3-D shape functions from finite element methods for the spatio-temporal interpolation of 2-D spatial and 1-D(More)
Transcriptional activator-like effectors (TALEs) are proteins secreted by Xanthomonas bacteria when they infect plants. TALEs contain a modular DNA binding domain that can be easily engineered to bind any sequence of interest, and have been used to provide user-selected DNA-binding modules to generate chimeric nucleases and transcriptional activators in(More)