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Revaprazan hydrochloride (RH) is a new reversible proton pump inhibitor. However, due to poor water solubility, oral bioavailability of the drug was relatively low. To investigate the particle size reduction effect of RH on dissolution and absorption, three suspensions that containing different sized particles were prepared by high pressure homogenization(More)
In recent research of wireless communication, the concept of cooperative diversity has been put forward and used widely. A number of transmission schemes designed for radio communications could not be directly applied to underwater network, where channel characteristics are more complicated. In this paper, we consider a situation comparatively closer to the(More)
Micelles from the mixture of poly(ethylene glycol)-phosphatidyl ethanolamine conjugate (PEG-PE) and d-alpha-tocopheryl polyetheyene glycol 1000 succinate (TPGS) were prepared loaded with the poorly soluble anticancer drug camptothecin (CPT). The solubilization of CPT by the mixed micelles was more efficient than with earlier described micelles made of(More)
The aim of the present study was to develop a transdermal drug delivery system for azasetron and evaluate the correlation between in vitro and in vivo release. The effects of different adhesives, permeation enhancers, and loadings of azasetron used in patches on the penetration of azasetron through rabbit skin were investigated using two-chamber diffusion(More)
The aim of this work was to investigate the effect of the stability of hydrogen-bonded ion pairs with organic amines on transdermal penetration of teriflunomide (TEF). Five organic amines, diethylamine (DEtA), triethylamine (TEtA), diethanolamine (DEA), triethanolamine (TEA), and N-(2'-hydroxyethanol)-piperdine (NP), were chosen to form ion pairs with TEF(More)
Anastrozole is a potent aromatase inhibitor and there is a need for an alternative to the oral method of administration to target cancer tissues. The purpose of the current study was to prepare a drug-in-adhesive transdermal patch for anastrozole and evaluate this for the site-specific delivery of anastrozole. Different adhesive matrixes, permeation(More)
  • Jie Liu, Zhongyan Wang, +6 authors Liang Fang
  • Drug development and industrial pharmacy
  • 2012
OBJECTIVE To design and optimize a drug-in-adhesive (DIA) type transdermal patch for tolterodine (TOL) based on acrylic and silicone matrixes. METHODS Initial in vitro studies were conducted to optimize the formulations. Two types of adhesive matrixes, drug loading, and enhancers were evaluated on the TOL transport across rabbit skin. For in vivo studies,(More)
In this paper, we investigate the construction of time-varying convolutional low-density paritycheck (LDPC) codes derived from block LDPC codes based on improved progressive edge growth (PEG) method. Different from the conventional PEG algorithm, the parity-check matrix is initialized by inserting certain patterns. More specifically, the submatrices along(More)
In this paper, we consider the protograph low-density parity-check (LDPC) codes in two-dimensional inter two-dimensional (2D) intersymbol interference (ISI) channels, which are widely used in modeling ultra-high-density magnetic recoding systems. In particular, we study the convergence and error performance of protograph codes over 2D-ISI channels. We(More)