Liwei Ma

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Using a suppressive subtractive hybridization system, we identified CSIG (cellular senescence-inhibited gene protein; RSL1D1) that was abundant in young human diploid fibroblast cells but declined upon replicative senescence. Overexpression or knockdown of CSIG did not influence p21(Cip1) and p16(INK4a) expressions. Instead, CSIG negatively regulated PTEN(More)
In this paper, we propose a novel simulation algorithm for large scale structured power grid networks. The new method formulates the traditional linear system as a special two-dimension Poisson equation and solves it using an analytical expressions based on FFT technique. The computation complexity of the new algorithm is <i>O</i>(<i>NlgN</i>), which is(More)
Lung cancer (LC) with its different subtypes is generally known as a therapy resistant cancer with the highest morbidity rate worldwide. Therapy resistance of a tumor is thought to be related to cancer stem cells (CSCs) within the tumors. There have been indications that the lung cancer is propagated and maintained by a small population of CSCs. To study(More)
Cellular senescence-inhibited gene (CSIG) protein significantly prolongs the progression of replicative senescence, but its role in tumorigenesis is unclear. To reveal the role of CSIG in HCC, we determined its expression in HCC tissues and surrounding tissues and its functions in tumor cell proliferation in vitro and in vivo. CSIG protein was overexpressed(More)
Cellular senescence-inhibited gene (CSIG), also named as ribosomal_L1 domain-containing 1 (RSL1D1), is implicated in various processes including cell cycle regulation, cellular senescence, apoptosis, and tumor metastasis. However, little is known about the regulatory mechanism underlying its functions. To screen important targets and signaling pathways(More)
BACKGROUND To systematically evaluate the visual performance of aspheric AcrySof IQ and spherical AcrySof Natural intraocular lens (IOL) after cataract surgery. METHODOLOGY/PRINCIPAL FINDINGS Potential randomized controlled trials (RCTs) that involved implanting AcrySof IQ and AcrySof Natural were searched from PubMed, Web of science, EMBASE, Chinese(More)
Early stage power estimation is critical for SoC architecture exploration and validation in modern VLSI design, but real-time, long time interval and accurate estimation is still challenging for system-level estimation and software/hardware tuning. This work proposes a model abstraction approach for real-time power estimation in the manner of machine(More)
Application specific on-chip network is a promising direction for networks on chips (NoCs) to solve the interconnection challenges that systems on chips (SoCs) will encounter in the billion-transistor age. This paper presents a novel design methodology named on-chip network evolution, which helps developing an on-chip network rapidly according to a specific(More)
Copyright: © 2016 Ma L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract To explore the genetic mechanism of replicative senescence, we identified and(More)