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Search and recommendation systems must include contextual information to effectively model users' interests. In this paper, we present a systematic study of the effectiveness of five variant sources of contextual information for user interest modeling. Post-query navigation and general browsing behaviors far outweigh direct search engine interaction as an(More)
This paper presents a new algorithm to automatically solve algebra word problems. Our algorithm solves a word problem via analyzing a hypothesis space containing all possible equation systems generated by assigning the numbers in the word problem into a set of equation system templates extracted from the training data. To obtain a robust decision surface,(More)
MiR-145 could regulate tumor growth, apoptosis, migration, and invasion. In our present study, we investigated its role in epithelial-mesenchymal transition (EMT). Expression of miR-145 was decreased in breast tumor tissues at T3&4 stages in comparison with those at T1&2. Over-expression of miR-145 mimics enhanced protein levels of E-cadherin and dampened(More)
BACKGROUND Consumer use of mobile devices as health service delivery aids (mHealth) is growing, especially as smartphones become ubiquitous. However, questions remain as to how consumer traits, health perceptions, situational characteristics, and demographics may affect consumer mHealth usage intentions, assimilation, and channel preferences. OBJECTIVE We(More)
We introduce a method for evaluating the relevance of all visible components of a Web search results page, in the context of that results page. Contrary to Cranfield-style evaluation methods, our approach recognizes that a user's initial search interaction is with the result page produced by a search system, not the landing pages linked from it. Our key(More)
Whole page relevance defines how well the surface-level repre-sentation of all elements on a search result page and the corre-sponding holistic attributes of the presentation respond to users' information needs. We introduce a method for evaluating the whole-page relevance of Web search engine results pages. Our key contribution is that the method allows us(More)
Nucleases containing programmable DNA-binding domains can alter the genomes of model organisms and have the potential to become human therapeutics. Here we present DNA-binding phage-assisted continuous evolution (DB-PACE) as a general approach for the laboratory evolution of DNA-binding activity and specificity. We used this system to generate transcription(More)
Fatty acid-derived biofuels and biochemicals can be produced in microbes using β-oxidation pathway engineering. In this study, the β-oxidation pathway of Saccharomyces cerevisiae was engineered to accumulate a higher ratio of medium chain fatty acids (MCFAs) when cells were grown on fatty acid-rich feedstock. For this purpose, the haploid deletion strain(More)
The transcription factor cAMP response element-binding protein (CREB) plays an important role in opioids dependence. To better understand the role of CREB in opioids dependence and underlying signal pathways, we compared the effects of three ohmfentanyl stereoisomers ((-)-cis-(3R,4S,2'R) OMF (F9202), (+)-cis-(3R,4S,2'S) OMF (F9204), (-)-cis-(3S,4S,2'R) OMF(More)
Production of biofuels derived from microbial fatty acids has attracted great attention in recent years owing to their potential to replace petroleum-derived fuels. To be cost competitive with current petroleum fuel, flux toward the direct precursor fatty acids needs to be enhanced to approach high yields. Herein, fatty acyl-CoA metabolism in Saccharomyces(More)