Liuzhong Yang

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UNLABELLED Understanding the excretion pathway is one of the most important prerequisites for the safe use of nanoparticles in biomedicine. However, the excretion of nanoparticles in animals remains largely unknown, except for some particles very small in size. Here we report a novel natural pathway for nanoparticle excretion, the intestinal goblet cell(More)
A novel scheme for item-based recommendation is proposed in this paper. In our framework, the items are described by an undirected weighted graph Q = (V,epsiv). V is the node set which is identical to the item set, and epsiv is the edge set. Associate with each edge eij isin epsiv is a weight omegaij ges 0, which represents similarity between items i and j.(More)
An increasing number of studies have suggested that microRNAs (miRNAs) are aberrantly expressed in numerous types of tumors and that a deregulation in miRNA expression may lead to carcinogenesis. Although miR‑218 has been demonstrated to be downregulated in several types of cancer, including medulloblastoma (MB), its involvement in MB is unclear. In the(More)
BACKGROUND/AIMS Recent reports showed that proteasome subunit alpha type-7 (PSMA7) was overexpressed in colorectal cancer. To investigate the mechanism of PSMA7 in promotion of colorectal cancer, we screened for its interaction partners. METHODS AND RESULTS This study found that PSMA7 associated with nucleotide-binding oligomerization domain-containing(More)
BACKGROUND/AIMS Although early studies show that Mdm2 is the primary E3 ubiquitin ligase for the p53 tumor suppressor, an increasing amount of data suggests that p53 ubiquitination and degradation are more complex than once thought. Here, we investigated the role of RNF125, a non-Mdm2 ubiquitin-protein ligase, in the regulation of p53. METHODS AND RESULTS(More)
Base on the development of geographic information application system (GIAS) building technology and the demand of "vertical multi-level and lateral multi-branch" organization for industry geographic information applications, in the paper, we reveals the background and necessity to establish the GIAS platform and the multilevel structure-oriented GIAS(More)
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