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Ochratoxin A Producing Fungi, Biosynthetic Pathway and Regulatory Mechanisms
This review focuses on three aspects of OTA: OTA-producing strains, OTA biosynthetic pathway and the regulation mechanisms of Ota production.
Procyanidin Promotes Translocation of Glucose Transporter 4 in Muscle of Mice through Activation of Insulin and AMPK Signaling Pathways
- Y. Yamashita, Liuqing Wang, Fumio Nanba, Chiaki Ito, T. Toda, H. Ashida
- Biology, ChemistryPloS one
- 6 September 2016
Procyanidins, especially cinnamtannin A2, one of the tetramers, was the most effective and significantly ameliorate postprandial hyperglycemia at least in part by promoting GLUT4 translocation to the plasma membrane by activating both insulin- and AMPK-signaling pathways.
pH-Signaling Transcription Factor AopacC Regulates Ochratoxin A Biosynthesis in Aspergillus ochraceus.
- Yan Wang, Fei Liu, Yang Liu
- Biology, EngineeringJournal of agricultural and food chemistry
- 13 April 2018
It is suggested that AopacC is an alkaline-induced regulator responsible for growth and OTA biosynthesis in A. ochraceus and this regulatory mechanism might be pH-dependent.
Elevated frequency of IL‐37‐ and IL‐18R&agr;‐positive T cells in the peripheral blood of rheumatoid arthritis patients
The mechanisms of ameliorating effect of a green tea polyphenol on diabetic nephropathy based on diacylglycerol kinase α
- Daiki Hayashi, Liuqing Wang, Shuji Ueda, M. Yamanoue, H. Ashida, Y. Shirai
- BiologyScientific Reports
- 16 July 2020
EGCg ameliorated albuminuria in DN through DGKα in vivo, and methylated EGCg, which has higher absorption in the plasma improved albuminia in DN effectively, indicating that the DGK α pathway is an attractive therapeutic target and that activating this pathway is a novel strategy for treating DN.
Oolong, black and pu-erh tea suppresses adiposity in mice via activation of AMP-activated protein kinase.
- Y. Yamashita, Liuqing Wang, Lihua Wang, Yukitaka Tanaka, Tianshun Zhang, H. Ashida
- BiologyFood & function
- 24 September 2014
The results indicate that oolong, black and pu-erh tea, and in particular, black tea, suppresses adiposity via phosphorylation of the key metabolic regulator AMPK and increases browning of WAT.
A Consensus Ochratoxin A Biosynthetic Pathway: Insights from the Genome Sequence of Aspergillus ochraceus and a Comparative Genomic Analysis
A consensus OTA biosynthesis pathway exists in all OTA-producing fungi and is encoded by a gene cluster containing four highly conserved biosynthetic genes and a bZIP transcription factor and is demonstrated to be consensus.
Functional Characterization of New Polyketide Synthase Genes Involved in Ochratoxin A Biosynthesis in Aspergillus Ochraceus fc-1
This study suggests that AoOTApks-1 could be involved in OTA biosynthesis, while AoOT Apks-2 might be indirectly involved in ochratoxin A production.
LncRNA MALAT1 Suppression Protects Endothelium against oxLDL-Induced Inflammation via Inhibiting Expression of MiR-181b Target Gene TOX
It is demonstrated that MALAT1 was upregulated in patients with AS and protects the endothelium from oxLDL-induced inflammation and oxidative stress in endothelial cells by upregulation of miR-181b and downregulation of TOX.