Liubov I. Kolesnikova

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We studied the contribution of the transformation of the catalytic properties of cerebral monoamine oxidase in the development of behavioral disorders during stress. Monoamine oxidase activities and catalytic characteristics, LPO intensity, and oxidative modification of proteins in suspension of the brain mitochondria were evaluated over the course of(More)
The antioxidant system of blood is the important factor that characterizes the adaptive possibilities of human organism. The estimation of state of the antioxidant protection and lipid peroxidation systems at men and women of two Baikal Lake ethnic groups was carried out. Spectrophotometric and fluorometric methods were used during the study. Increase of(More)
We studied parameters of lipid peroxidation (LPO) in women with infertility, resident of the Republic of Buryatia. The levels of malonic dialdehyde (MDA) were increased in the examined infertile women from Buryat and Russian populations. Reduced total antioxidant activity, activity of superoxide dismutase (SOD), and α-tocopherol levels were revealed in(More)
We studied the state of the LPO–antioxidant defense system in men aged from 46 to 55 years. The main group included patients with obstructive sleep breathing disorders. The state of the antioxidant defense system was assessed by measuring the blood levels of LPO substrates with conjugated double bonds, conjugated dienes, ketodienes and conjugated trienes,(More)
Here we performed individual evaluation of the oxidative stress index that serves as an integral criterion for the balance of LPO–antioxidant defense system in women with endocrine pathology (type 1 diabetes mellitus and infertility with hyperprolactinemia). The state of the LPO–antioxidant defense system was estimated from blood levels of LPO substrates(More)
Oxidative stress plays an important role in the pathogenesis the most of diseases. Important components of protecting cells from oxidative stress are antioxidant enzymes. Antioxidant enzymes are characterized by population differences in enzyme activity. The purpose of the study to summarize and discuss information on genetic polymorphisms of antioxidant(More)
Experiments on rat model of toxic liver damage (CCl4, subcutaneously) have demonstrated that selenium nanopreparation on arabinogalactan matrix and partially arabinogalactan alone prevented the development of oxidative stress assessed by the balance of LPO and antioxidant defense processes.
The distribution of genotypes and alleles of Q192R polymorphism of the paraoxonase1 (rs622) gene was studied in Russian and Buryat populations living in Eastern Siberia. Correlations between genotypes and some parameters of the lipid profile and lipid peroxidation indicators were revealed. In the group of Russians, the frequency of genotypes was QQ—0.354;(More)
The study of LPO processes in adolescents of different races with essential hypertension revealed that Mongoloids exhibit oxidative stress by altering the level of the formation of diene conjugates, the primary LPO products. Caucasians increased the levels of both primary and end products of LPO, diene conjugates, and malondialdehyde. The revealed(More)
There was performed a comparative evaluation of the mean values of lipid metabolism parameters in youths and girls of the indigenous population (the Even), of the coming population of the north of Irkutsk province, and of the province center (the Europeoids). Gender differences in HDLP have been revealed in adolescents of the coming population, in the(More)