Liu Shu-mao

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In this study cytogenetic analysis of 5 cases of acute promyelocytic leukemia (APL) is described and 3 (60%) of them showed t(15; 17) in karyotype. In recent years more than 130 cases of hematological disorders were studied cytogenetically in our laboratory and this kind of translocation has not been found except in APL. As shown in these patients t(l5; l7)(More)
In this paper chromosome study with synchronization of bone marrow culture technique in patients with leukemia is reported. This technique provided a large number of elongated, analyzable mitoses, greatly facilitating chromosome analysis. Satisfactory results were obtained in 92.7 % of 41 patients with acute nonlymphocytic leukemia. Furthermore, fluorescent(More)
The distribution and excretion of intravenous injected3H-rhomotoxin was studied in mice. The radioactivity of3H-rhomotoxin was found to be high in gall bladder, liver and kidney, lower in thyroid gland, adrenal gland, heart and lungs, and lowest in brain. 52.4% of the drug was excreted in urine and feces within 6 h. Rhomotoxin was bound to plasma protein(More)
DNA from 36 patients with chronic myelogenous leukemia (CML) at various clinical stages and 6 cases of acute leukemia was investigated for alterations of the p53 gene by Southern blot analysis. Rearrangements of the p53 gene were seen in 3 of 12 (25.00%) cases of blast crisis and accelerated phase (AP) of CML and in only one of 18 chronic phrase (CP), just(More)
Cytogenetic studies were made in 22 patients with acute myelocytic leukemia (AML) (M2), in 12 of whom the banding analysis was satisfactory. 4 of these 12 cases (33.3%) were proved to have 8;21 translocation, among whom one was an adult and the other 3 children. 2 male patients showed loss of Y chromosome and the karyotype was 45,X,-Y,t(8q−, 2lq+); one(More)
To induce the expression of fragile sites, PHA-stimulated lymphocytes during the last 24 h of culture were incubated either in 199 medium which is relatively deficient in folic acid or in 1640 medium supplemented by MTX or FdU. Blood samples from 20 patients and 12 controls were examined. At the same time the cytogenetic study of bone marrow cells from the(More)
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