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A four year prospective study of age-related cognitive change in adults with Down's syndrome.
BACKGROUND While neuropathological studies indicate a high risk for Alzheimer's disease in adults with Down's syndrome, neuropsychological studies suggest a lower prevalence of dementia. In thisExpand
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Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB
Results of a placebo controlled cross-over trial (N=89) of the anticholinesterase drug THA as a treatment for dementia of the Alzheimer's type (DAT) are reported, with reference to previous trials ofExpand
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Self-injurious behavior in Rett syndrome: Interactions between features of Rett syndrome and operant conditioning
Operant and biological theories of the cause of self-injurious behavior (SIB) in people with a mental handicap are often viewed as mutually exclusive. In this single case study, interactions betweenExpand
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Effects of increasing task load on memory impairment in adults with Down syndrome.
The effect of increasing the number of stimuli to be recalled was investigated to evaluate whether sensitivity for memory impairment was enhanced in adults with Down syndrome when using higher taskExpand
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Allelic variability in D21S11, but not in APP or APOE, is associated with cognitive decline in Down syndrome
GENETIC variation in the APOE gene and variation in chromosome 21 genotypes, including the APP locus, may influence age-associated cognitive decline in adults with Down syndrome. Molecular geneticExpand
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The Neuropsychological Assessment of Age Related Cognitive Deficits in Adults with Down's Syndrome
There is substantial evidence that older adults who have Down's syndrome are at risk for developing Alzheimer's disease. However, whilst the neuropathological signs of Alzheimer's disease are almostExpand
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Cognitive deterioration in adults with Down syndrome: effects on the individual, caregivers, and service use.
Individuals with Down syndrome (N = 49) who had participated in serial neuropsychological assessments were assigned to one of three groups comparable in level of premorbid mental retardation: thoseExpand
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Public transit 1993: Bus, paratransit, and ridesharing. Transportation research record
Contents: evaluation of the operating cost consequences of signal preemption as an IVHS strategy; efficient transit priority at intersections; welfare comparison of fixed- and flexible-route busExpand
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